Patients with HIV may also have simultaneous chronic medical conditions, resulting in the possibility of complex drug-drug interactions. 29. Unable to load your collection due to an error While all agents in the class have been shown to produce some changes, each drug has its own specific risk profile. 2002;2(2):91-106. doi: 10.2165/00129784-200202020-00003.Wearne N, Davidson B, Blockman M, Swart A, Jones ES.Drugs Context. Safe pharmacological treatment of these complications requires an understanding of the drug-drug interactions between antiretroviral drugs and the drugs used in the treatment of metabolic complications. Unrecognized, DDIs can lead to toxicities or underdosing with a decrease in drug efficacy
2019 Jun 1;252:450-457. doi: 10.1016/j.jad.2019.04.018. Thus, the lactone prodrugs simvastatin and lovastatin should not be used with HIV protease inhibitors. 1999 Apr;33(4):461-73. doi: 10.1345/aph.18240.Clin Drug Investig. A detailed review of concomitant medications can help in creating a regimen that minimizes undesirable interactions. Sulfonylurea drugs utilise mainly CYP2C9 for metabolism, and this isoenzyme may be induced by ritonavir and nelfinavir with a resulting decrease in efficacy of the sulfonylurea. Interactions between Antipsychotics and … 1999 Apr;36(4):289-304. doi: 10.2165/00003088-199936040-00004.Hsyu PH, Schultz-Smith MD, Lillibridge JH, Lewis RH, Kerr BM.Antimicrob Agents Chemother. Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals. We would like to show you a description here but the site won’t allow us. 2017 Oct;4(5):371-375. doi: 10.1089/lgbt.2017.0057. Name must be less than 100 characters This site needs JavaScript to work properly. You should avoid or limit the use of alcohol while being treated with ARIPiprazole. 2020 Jul 9:S0025-7753(20)30450-4. doi: 10.1016/j.medcli.2020.06.026. doi: 10.2165/00003088-200241140-00004.
doi: 10.1128/AAC.00910-19. Psychotropic medications are frequently co-prescribed with antiretroviral therapy (ART), owing to a high prevalence of psychiatric illness within the population living with HIV, as well as a 7-fold increased risk of HIV infection among patients with psychiatric illness.
2019 Oct 22;63(11):e00910-19. Ritonavir and nelfinavir also induce a host of CYP isoforms as well as some conjugating enzymes. Drugs. Please enable it to take advantage of the complete set of features! Drug interaction studies have been performed with HIV protease inhibitors and HMG-CoA reductase inhibitors. Cambridge University Press
COVID-19 is an emerging, rapidly evolving situation. 2020 May 18. doi: 10.1016/j.psym.2020.05.006. 2020 Mar 10;9:2019-11-1. doi: 10.7573/dic.2019-11-1. While ART has been notoriously associated with a multitude of pharmacokinetic drug interactions involving the cytochrome P450 enzyme system, the magnitude and clinical impact of these interactions with psychotropics may range from negligible effects on plasma concentrations to life-threatening torsades de pointes or respiratory depression. eCollection 2020.Duwal S, Seeler D, Dickinson L, Khoo S, von Kleist M.Front Pharmacol. Database of Antiretroviral Drug Interactions. On Jun, 11, 2020. Epub 2020 Apr 27.Brandariz-Nuñez D, Correas-Sanahuja M, Guarc E, Picón R, García B, Gil R.Med Clin (Barc). We comply with the HONcode standard for trustworthy health information - Springer This comprehensive review summarizes the currently available information regarding drug-drug interactions between antiretrovirals and pharmacologic agents utilized in the treatment of psychiatric disorders-antidepressants, stimulants, antipsychotics, anxiolytics, mood stabilizers, and treatments for opioid use disorder and alcohol use disorder-and provides recommendations for their management. 2017 Feb 22;8:6-14. doi: 10.1016/j.jcte.2017.01.004. Some people may also experience impairment in thinking and judgment. We comply with the HONcode standard for trustworthy health information - Ritonavir is the most potent inhibitor of CYP3A4. eCollection 2017 Jun.Braun HM, Candelario J, Hanlon CL, Segura ER, Clark JL, Currier JS, Lake JE.LGBT Health. HIV Drug Interactions. doi: 10.2165/00003088-200241140-00004. Since formal studies of most of these interactions have not been performed, predictions must be based on our understanding of the metabolism of these agents. All HIV protease inhibitors are metabolised by and inhibit cytochrome P450 (CYP) 3A4. Clipboard, Search History, and several other advanced features are temporarily unavailable.
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