0000005233 00000 n This includes any possible side effects not listed in this leaflet. Peak plasma concentrations in the fasting state occur between 0.5 and 1.5 hours post-dose. Male rats treated with 5 and 10 mg/kg/day had an increased incidence of hepatocellular adenomas.

Clinical data indicate that children have a higher fluconazole clearance than observed for adults. • If you get any side effects, talk to your doctor or pharmacist. Cytogenetic studies in vivo (murine bone marrow cells, following oral administration of fluconazole) and in vitro (human lymphocytes exposed to fluconazole at 1000 μg/ml) showed no evidence of chromosomal mutations.Fluconazole did not affect the fertility of male or female rats treated orally with daily doses of 5, 10, or 20 mg/kg or with parenteral doses of 5, 25, or 75 mg/kg. 0000001597 00000 n

• To reduce the incidence of recurrent vaginal candidiasis (4 or more episodes a year). This includes candidiasis, blastomycosis, coccidiodomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and pityriasis versicolor. 0000007175 00000 n Fluconazole is also an inhibitor of CYP2C19. Fluconazole 200 mg to 400 mg daily has no clinically significant effect on endogenous steroid levels or on ACTH stimulated response in healthy male volunteers. Continue typing to refine. In patients with severe renal insufficiency, (GFR< 20 ml/min) half life increased from 30 to 98 hours. 0000033244 00000 n Some azoles, including fluconazole, have been associated with prolongation of the QT interval on the electrocardiogram. The body has “FC 100” and the cap has “G” printed in black. The average fluconazole plasma elimination half-life varied between 15 and 18 hours and the distribution volume was approximately 880 ml/kg after multiple doses.

Of a radioactive dose, only 11% is excreted in a changed form in the urine. Such a hormone change has not been observed in women treated with fluconazole (see section 5.1). In patients with fungal meningitis, fluconazole levels in the CSF are approximately 80% the corresponding plasma levels. Patients who develop abnormal liver function tests during fluconazole therapy must be monitored closely for the development of more serious hepatic injury. 0000000016 00000 n 0000054554 00000 n Coadministration of other medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P450 (CYP) 3A4 such as cisapride, astemizole, pimozide, quinidine and erythromycin are contraindicated in patients receiving fluconazole (see sections 4.4 and 4.5). There have been reports of uveitis in patients to whom fluconazole and rifabutin were coadministered. 0000054269 00000 n Fluconazole. 0000006609 00000 n

0000083631 00000 n ยา Fluconazole (ฟลูโคนาโซล) - เป็นยากลุ่มยาต้านเชื้อรา เผยแพร่ครั้งแรก 30 ก.ค. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcardor search for MHRA Yellow Card in the Google play or Apple App storeThere have been reports of overdose with Fluconazole capsule and hallucination and paranoid behaviour have been concomitantly reported. If patients with invasive/systemic fungal infections develop rashes, they should be monitored closely and fluconazole discontinued if In rare cases anaphylaxis has been reported (see section 4.3).Fluconazole is a moderate CYP2C9 and CYP3A4 inhibitor. The mean half-life (hours) was 74 (range 44-185) on day 1 which decreased, with time to a mean of 53 (range 30-131) on day 7 and 47 (range 27-68) on day 13. The long plasma elimination half-life provides the basis for single dose therapy for vaginal candidiasis, once daily and once weekly dosing for other indications. Ten of these patients were concomitantly receiving diuretics. Beli FLUCONAZOLE KF 150MG di K24klik, 100% asli dan dapatkan manfaatnya untuk mengobati infeksi candida akibat jamur.

We make every effort to keep it current, however, there may be times when a drug is listed here but not temporarily available with us.

0000001823 00000 n

Up to 28 days. The evidence for efficacy of fluconazole in the treatment of cryptococcosis of other sites (e.g. In patients (including paediatric population) with impaired renal function who will receive multiple doses of fluconazole, an initial dose of 50 mg to 400 mg should be given, based on the recommended daily dose for the indication. When suggestions are available use up and down arrows to review and ENTER to select. BLOCATENS C.TAB 10MG/TAB BTX30(3 BL X10) Uni-Pharma Α.Ε. We, Mediflora Pharmacy aim at growing market and increasing our network of customers as prominent leading Exporter, Supplier, Distributor and Trader of Fluconazole Tablet based In …

Ketoconazole is known to cause adrenal insufficiency, and this could also although rarely seen be applicable to fluconazole. Fiorinal C: This medication is used for the relief of acute and chronic pain of a mild, moderate, or severe degree that is accompanied by tension or anxiety. 150 mg every third day for a total of 3 doses (day 1, 4, and 7) followed by 150 mg once weekly maintenance dose Treatment should be continued until infected nail is replaced (uninfected nail grows in). The accumulation of 14 alpha-methyl sterols correlates with the subsequent loss of ergosterol in the fungal cell membrane and may be responsible for the antifungal activity of fluconazole.

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