The highest dose used in the rat and mouse teratogenicity studies was equivalent to a clindamycin phosphate dose of 432 mg/kg. The site of binding appears to be in the 50S sub-unit of the ribosome. The only thing which varies in treating a child with antibiotic therapy is the concentration of drug in the child. It is sebostatic, comedolytic, and inhibits growth of Some evidence suggests that benzoyl peroxide has an anti-inflammatory effect as well. Therefore, it should be used with caution in patients receiving such agents.The carcinogenicity of a 1% clindamycin phosphate gel similar to Clindamycin Phosphate Topical Gel was evaluated by daily application to mice for 2 years. Loosens the outer horny layer of epidermis The nurse is assessing a patient with plaque psoriasis who … It penetrates well into abscesses and is actively taken up and concentrated by phagocytes, polymorphonuclear leukocytes, and alveolar macrophages.Only ~10% clindamycin is excreted unchanged in the urine, and small quantities are found in the faeces. Clindamycin Phosphate Topical Gel, 1%, a topical antibiotic, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram in a gel vehicle consisting of carbomer 941, methylparaben, polyethylene glycol 400, propylene glycol, purified water, and sodium hydroxide. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.Safety and effectiveness in children under the age of 12 have not been established.The clinical study with Clindamycin Phosphate Topical Gel did not include sufficient numbers of patients aged 65 and over to determine if they respond differently than younger patients.In the one well-controlled clinical study comparing Clindamycin Phosphate Topical Gel and its vehicle, the incidence of skin and appendages adverse events occurring in ≥1% of the patients in either group is presented below:Orally and parenterally administered clindamycin has been associated with severe colitis, which may end fatally.Cases of diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see To report SUSPECTED ADVERSE REACTIONS, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.Topically applied Clindamycin Phosphate Topical Gel may be absorbed in sufficient amounts to produce systemic effects (see WARNINGS).Apply a thin film of Clindamycin Phosphate Topical Gel once daily to the skin where acne lesions appear. Use of the topical formulation of clindamycin results in absorption of theantibiotic from the skin surface. Available for Android and iOS devices. It binds on the 50S subunit of the bacterial ribosome. Ingestion can cause widespread liver necrosis, extensive gastrointestinal ulceration with scarring and stenosis; a severe metabolic acidosis can occur, through accumulation of formic acid and other organic acids, and can result in neurological damage, including optic nerve damage; During this study 22 trials involving 2212 participants were identified; 12 trials compared BPO as single agent, while the other 10 trials compared BPO in combination products. Plasma protein binding is > 90 %. No significant increase in tumors was noted in the treated animals.A 1% clindamycin phosphate gel similar to Clindamycin Phosphate Topical Gel caused a statistically significant shortening of the median time to tumor onset in a study in hairless mice in which tumors were induced by exposure to simulated sunlight.Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion test. does so through competitive inhibition on PCB (penicllin binding proteins) peptidoglycan layer is important for cell wall structural integrity. Clindamycin is a semi-synthetic and belongs to lincosamide.It has a molecular weight of 504.96, and the molecular formula is C18H34ClN208PS Its chemical structure is:Clindamycin is bacteriostatic drug acts by inhibiting protein synthesis. Use enough to cover the entire affected area lightly.Clindamycin Phosphate Topical Gel containing clindamycin phosphate equivalent to 10 mg clindamycin per gram, is available in the following size:The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The daily doses used in this study were approximately 3 and 15 times higher than the human dose of clindamycin phosphate from 5 mL of Clindamycin Phosphate Topical Gel, assuming complete absorption and based on a body surface area comparison. Drug Interactions: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Itfreely crosses the placenta. All Rights Reserved. There was no signal for contact sensitization in the clinical trials under normal use conditions.Clindamycin Phosphate Topical Gel is indicated for topical application in the treatment of acne vulgaris. These studies revealed no evidence of fetal harm. It is often used as a convenient oxidant in organic chemistry.Benzoyl peroxide breaks down in contact with skin, producing In a 1977 study using a human maximization test, 76% of subjects acquired a contact sensitization to benzoyl peroxide.
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