Because of the potential for serious adverse reactions in nursing infants, clindamycin should not be taken by nursing mothers.Fertility studies in rats treated orally with clindamycin revealed no effects on fertility or mating ability.Clindamycin has no or negligible influence on the ability to drive and use machines.The table below lists the adverse reactions identified through clinical trial experience and post-marketing surveillance by system organ class and frequency. Diagnosis is usually made by the recognition of the clinical symptoms, but can be substantiated by endoscopic demonstration of pseudomembranous colitis.
It's FREE to register and you'll have access to drug information and much more. In vitro studies in human liver and intestinal microsomes indicated that clindamycin is predominantly oxidized by CYP3A4, with minor contribution from CYP3A5, to form clindamycin sulfoxide and a minor metabolite, N-desmethylclindamycin.
Clindamycin should be used in pregnancy only if clearly needed.Orally and parenterally administered clindamycin has been reported to appear in human breast milk in ranges from 0.7 to 3.8µg/mL. Although clindamycin phosphate is inactive Resistance to clindamycin usually occurs via macrolide-lincosamide-streptogramin B (MLSB) type of resistance, which may be constitutive or inducible.The minimum inhibitory concentrations (MIC) breakpoints are as follows:Gram positive anaerobes: sensitive ≤ 4 resistant > 4Efficacy is related to the ratio of the area of the concentration-time curve of unbound antibiotic to the MIC for the pathogen (fAUC/MIC).The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. Antibiotics Might Lower Effectiveness of Birth Control Pill Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s). La colite è usualmente caratterizzata da grave e persistente diarrea con Sono stati descritti alcuni rari casi di ricaduta dopo il trattamento con vancomicina.I dati finora disponibili mettono in luce che i pazienti anziani e/o gravemente ammalati tollerano meno bene la diarrea; qualora questi pazienti dovessero essere trattati con clindamicina occorre prestare particolare attenzione alle variazioni della frequenza dell'evacuazione.DALACIN C capsule deve essere prescritto con cautela ad individui con anamnesi positiva per malattie gastro-intestinali, particolarmente coliti, ed agli individui atopici.Talvolta l'uso di antibiotici può provocare lo sviluppo di germi resistenti, in particolare Non si raggiungono livelli significativi di clindamicina nel Il medicinale contiene lattosio.
Deve essere quindi utilizzata con cautela nei pazienti che assumono tali farmaci.È stata dimostrata una reattività crociata fra clindamicina e lincomicina.È stato dimostrato un antagonismo in vitro tra clindamicina ed La somministrazione di clindamicina e primachina in volontari HIV-positivi non ha influito significativamente sui parametri farmacocinetici della Alcuni antibiotici possono ridurre l'efficacia delle Gli studi sulla tossicità riproduttiva condotti su ratti e conigli a seguito di Negli studi clinici su donne in gravidanza, la somministrazione sistemica di clindamicina nel secondo e nel terzo trimestre non è risultata associata a un aumento della frequenza di anomalie congenite. The frequency grouping is defined using the following convention: Very common (≥1/10); Common (≥ 1/100 to <1/10); Uncommon (≥1/1,000 to <1/100); Rare (≥ 1/10,000 to <1/1,000); Very Rare (< 1/10,000); and Not known (cannot be estimated from the available data). Lincosamides such as clindamycin bind to the 50S subunit of the bacterial ribosome similarly to macrolides such as erythromycin and inhibit protein synthesis. This site uses cookies.
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