Therapeutic action – Anthelminthic (antifilarial) Indications – Lymphatic filariasis.
The interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells. Dorchies, Philippe
Terhell, A.J.
2001.
Figueredo-Silva, José An immunologic determinant in the pathogenesis of the Mazzotti reaction in human onchocerciasisThe chemotherapy of onchocerciasis. These parasites infect the blood and lymph channels in humans, causing the debilitating disease filariasis. Tsukidate, Setsuko 1998. Magnaval, Jean-François
We investigated whether DEC stimulates the production of NO from murine macrophages or rat endothelial cells. Rocha, Abraham Gutiérrez-Peña, E. J. However a combination of DEC (3 mg/kg) and styrylpyridinium chloride (5 mg/kg) gave protection against hookworms, ascarids and heartworms in dogs. 2002. Diethylcarbamazine is a microfilaricidal drug that is widely used, in particular for Loa Loa infections and lymphatic filariasis caused by Wuchereria bancrofti and Brugia malayi.It can be associated with significant systemic adverse effects, which can compromise adherence to therapy.
Florêncio, M.S
Rocha, Abraham 1999. Biosynthesis, metabolism, receptors, functions, and pharmacologyRegulation of parasite-induced eosinophilia: selectively increases interleukin 5 production in helminth-infected patientsIntravascular filarial parasites elaborate cyclooxygenase-derived eicosanoidsIncorporation of arachidonic acid by microfilariae of Brugia malayiTransactions of the Royal Society of Tropical Medicine and HygieneDiethylcarbamazine: a review of its action in onchocerciasis, lymphatic filariasis and inflammationImmunological tolerance: the key feature in human filariasis?Inhibition of leukotriene biosynthesis in mastocytoma cells by diethylcarbamazineSerum-dependent interaction of granulocytes with Onchocerca volvulus microfilariae in generalized and chronic hyper-reactive onchocerciasis and its modulation by diethylcarbamazineTransactions of the Royal Society of Tropical Medicine and HygieneStructure of slow-reacting substance of anaphylaxis from guinea-pig lungCytokine induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrinsThe immunodeficient scid mouse as a model for human lymphatic filariasis[Antimicrofilarial effect of diethylcarbamazine on microfilariae of Litomosoides carinii in the nude mouse.] 1996. Bandi, Claudio Fujita, Koichiro Didier, J.M. Yazdanbakhsh, M. Satyavan Sharma, Nitya Anand, in Pharmacochemistry Library, 1997. 2003.
Needham, C.S.
Please enable it to take advantage of the complete set of features! and Coutinho, Amaury Peixoto, C.A
CoA, QC data, MSDS will be provided when product is successfully made. Bandi, Claudio 1994. Norões, Joaquim Sound Post Type.
Zahner, Horst Recent data from two different laboratories suggest that NO may be involved in host defense against filarial parasites (T. V. Rajan et al., 1996, Infection and Immunity 64(8), 3351-3353; M. J. Taylor et al., 1996, Parasitology 112, 315-322). 2004 Apr;92(6):513-7. doi: 10.1007/s00436-004-1081-0.
Norões, Joaquim and and 1996. Mitsui, Y. Most supplements are designed to perform a specific function but Provestra is designed for a plethora of sexual dysfunctions.
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