However, during follow‐up, we found a large number of children describing late‐onset LT‐related symptoms. SYNTHROID® (levothyroxine sodium) tablets, for oral use is a prescription, man-made thyroid hormone that is used to treat a condition called hypothyroidism. My GP has lowered my dose of synthroid. A structured questionnaire was used. My TSH was .138. Generally, thyroid replacement treatment is to be taken for life. Smaller overdoses may go unnoticed and will produce effects such as an elevated heart rate and difficulty sleeping. Results are outlined in table A total of 29 of 181 (16%) patients described symptoms at the time of enquiry (table In total, 53 of 181 (29%) patients had ingested multiple drugs and they had more frequent symptoms than patients who had only ingested LT (A total of 153 of 181 (85%) patients had no symptoms of poisoning at the time DPIC was contacted. To evaluate the frequency of late‐onset symptoms, a subgroup of patients without initial symptoms were contacted. None of the cases resulted in contact to the healthcare system or in serious outcomes.The systematic review of the literature identified 20 cases and case series describing acute LT poisoning in children (table A review of the GSK safety database identified 47 cases (all younger than 14 years) involved in accidental LT exposure/overdose. None of them were serious or needed further treatment but should result in corresponding information to the patient. rash and if symptoms associated with allergy or hypersensitivity occur. 2.66$. They had ingested LT (as a single drug) in the dose range of 300–15000 mcg, and their symptoms started and ended within 24 hr. Therefore, it cannot be excluded that our findings are influenced by selection bias.
to 28 days (median 1 hr).
We were not able to determine whether adults were more sensitive to LT poisoning than children. A few patients reported manifestations in skin such as oral mucosal discolouration, cutaneous lichenoid eruption, skin exfoliation and alopecia.
The aim of this study was to identify factors associated with symptoms of poisoning including late‐onset symptoms. Their dosage of Synthroid may be adjusted as well.
and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Cases were based on literature search and reports from the consumers, physicians and other health professionals in the following countries: Argentina, Brazil, India, Israel, Germany, United Kingdom, United States, Switzerland, Spain and Canada. Therefore, we perceive this group as a representative sample of the DPIC inquiries.Thirdly, determining the time, amount ingested and symptoms is often difficult in children because of behavioural, comprehension and speech‐related challenges.
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