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In such patients, corticosteroid-induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia.Average and large doses of cortisone or hydrocortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. When dexamethasone sodium phosphate is given by intravenous infusion, only Sodium Chloride Injection BP or Glucose Injection BP should be used as diluents. Dexamethasone Sodium Phosphate, USP chemically is Pregna-1,4-diene-3,20-dione, 9-fluoro- 11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11ß, 16α). These may be changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness and the effect of stress (e.g. In the event of overdosage, no specific antidote is available; treatment is supportive and symptomatic.The oral LD50 of dexamethasone in female mice was 6.5 g/kg. Moreover, intra-uterine growth can be delayed. (See Since complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment a risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used. )The use of dexamethasone sodium phosphate injection, USP in active tuberculosis should be restriced to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with appropriate antituberculous regimen.If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. Blood should be drawn at 8am for plasma cortisol determination on the third morning.Twenty four hour urine collection should be employed for 17-hydroxycorticosteroid excretion determination.Dosage should be limited to a single dose on alternate days to lessen retardation of growth and minimize suppression of hypothalamo-pituitary-adrenal axis.Treatment of elderly patients, particularly if long term, should be planned bearing in mind the more serious consequences of the common side effects of corticosteroids in old age.For oral use.

Dexamethasone is metabolised via cytochrome P450 3A4 (CYP3A4). The empirical formula is CDexamethasone sodium phosphate injection, USP is a sterile solution of dexamethasone sodium phosphate, and is supplied in 4 mg/mL and 10 mg/mL. Since infusion solutions generally do not contain preservatives, mixtures should be used within 24 hours.The initial dosage of dexamethasone sodium phosphate injection varies from 0.5 to 0 mg a day depending on the disease being treated.

In certain overwhelming, acute, life-threatening situations, however, administration in dosages exceeding the usual dosages may be justified and may be in multiples of the oral dosages. Gastrointestinal topicals, antacids, charcoal: A decrease in digestive absorption of glucocorticoids have been reported with prednisolone and dexamethasone. All corticosteroids increase calcium excretion.While on corticosteroid therapy patients should not be vaccinated against smallpox. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Dexamethasone Sodium Phosphate USP, C22H28FNa2O8P, has a molecular weight of 516.41 and chemically is Pregn-4-ene-3, 20-dione, 9-fluoro-11, 17-dihydroxy-16-methyl-21 (phosphonooxy)-, disodium salt, (11β, 16α). Possible impact of corticosteroid therapy on the metabolism of oral anticoagulants and on clotting factors.

There may be decreased resistance and inability to localize infection when corticosteroids are used. It occurs as a white or slightly yellow crystalline powder, is odorless or has a slight odor of alcohol, is exceedingly hygroscopic and is freely soluble in water.

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