Search for other works by this author on: Recently, several medications, including orlistat, ciprofloxacin, and oral sodium phosphate solution, along with underlying risk factors have been described as causing crystal nephropathy. Observe infusion site for phlebitis. Drug-induced severe potassium disturbances were found in 32.3% of the cases, and in 23% were lethal; hypokalemia was present in 23.4% of life-threatening potassium disturbances [].Intravenous acyclovir is the most common therapy against herpes virus; it can induce crystalluria and lead to AKI. If you originally registered with a username please use that to sign in. EUR €37.00 Clipboard, Search History, and several other advanced features are temporarily unavailable. 1997;(16 Pt 1):556-9.Am J Kidney Dis. Postgraduate Year 1 Pharmacy Resident This article is also available for rental through DeepDyve. The drug may be administered topically to the skin, intravenously, orally, or topically to the …
Name must be less than 100 characters Taylor & Francis In this case, a transient period of hemo-concentration likely second-ary to dehydration may have contributed to a markedly elevated concentration of acyclovir in the urine. Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus DNA polymerase. The drug may be administered topically to the skin, intravenously, orally, or topically to the eye (only topical and … Clipboard, Search History, and several other advanced features are temporarily unavailable. … Don't already have an Oxford Academic account? COVID-19 is an emerging, rapidly evolving situation. Am J Med Sci 1993; 305:36. The case described in this vignette is an example of the clinical manifestation of acyclovir crystal obstructive nephrotoxicity. Annu Rev Med. It is characterized by a decrease in renal function that develops within 24–48 hours of acyclovir administration indicated by a rapid rise in the serum creatinine. The most important adverse effect is crystalluria and elevated serum creatinine related to bolus intravenous administration. 1988;20(2):225-8. doi: 10.3109/00365548809032442.J Antimicrob Chemother. It shows good in vitro activity against herpes simplex and varicella-zoster viruses. Nephrol Ther 2010; 6:125. To purchase short term access, please sign in to your Oxford Academic account above. -Acyclovir is the oral drug of choice for treating herpes zoster in HIV-infected children; it should be given for 7 to 10 days, although longer durations should be considered if lesions are slow to resolve.-Initial IV therapy is recommended in children with more severe immunosuppression. 1986 Nov-Dec;5(6):710-2. Name must be less than 100 characters High-risk patients. Thank you for submitting a comment on this article. 1. 1999 Apr;106(4):459-65. doi: 10.1016/s0002-9343(99)00041-8.Ryoikibetsu Shokogun Shirizu. 2020 Jun 27;9(7):2022. doi: 10.3390/jcm9072022.Sperati CJ, Zhang C, Delsante M, Gupta R, Bagnasco S, Barman I.Kidney Int Rep. 2018 Mar 23;3(4):997-1003. doi: 10.1016/j.ekir.2018.03.010. doi: 10.1097/00006454-198611000-00027. 1. 2010 Dec 30;8:139. doi: 10.1186/1479-5876-8-139.Antimicrob Agents Chemother.

It shows good in vitro activity against herpes simplex and varicella‐zoster viruses. USD $47.00 Failure to quickly realize this as an etiology of acute kidney injury can lead to excessive morbidity to the patient. We investigated the frequency of crystalluria and the renal drug safety in kidney transplant recipients treated with cyclosporin in whom oral valacyclovir was used for the prevention of CMV disease. Jovino Ocasio Hernandez, Jeni Norstrom, Glenn Wysock, Acyclovir-induced renal failure in an obese patient, Most users should sign in with their email address. Potter JL, Krill CE Jr. PMID: 3797306 [PubMed - indexed for MEDLINE] Publication Types: Safety and tolerance studies in animals and humans have shown acyclovir to be very well tolerated. Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus DNA polymerase. Dosage adjustment is required in patients with renal failure. 1 I.V. The appearance of acyclovir crystalluria is considered to be a warning sign which precedes the rise of the serum creatinine level . 2014 Jan;63(1):148-52. doi: 10.1053/j.ajkd.2013.06.023. Search for other works by this author on:

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