Prinivil is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old.. Prinivil is also used to treat congestive heart failure in adults, or to improve survival after a heart attack.. Dispense in tight container (USP).Female patients of childbearing age should be told about the consequences of exposure to amlodipine besylate and benazepril hydrochloride during pregnancy.
With chronic once daily administration, antihypertensive effectiveness is maintained for at least 24 hours.
Telephone numbers of certified poison-control centers are listed in the Physicians’ Desk Reference (PDR).
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Clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
2006;6(2):103-13. doi: 10.2165/00129784-200606020-00004.Integr Blood Press Control.
With abrupt return of peripheral vascular tone, overdoses of other dihydropyridine calcium channel blockers have sometimes progressed to pulmonary edema, and patients must be monitored for this complication.
Combination therapy was effective in blacks and nonblacks. Absorption from the individual tablets is not influenced by the presence of food in the gastrointestinal tract; food effects on absorption from amlodipine besylate and benazepril hydrochloride have not been studied.Carcinogenicity and mutagenicity studies have not been conducted with this combination.
Kyinegupsth ( site web ) | 12/11/2012 The most common reasons for discontinuation of therapy with amlodipine besylate and benazepril hydrochloride were cough and edema. Epub 2009 Oct 28.Clin Drug Investig. /viewarticle/937348
Fetal testing may be appropriate, based on the week of pregnancy. If hypotension occurs, the patient should be placed in the supine position and if necessary given physiological saline i.v.
Additionally, the amlodipine/benazepril combination product costs less than the same therapy administered … Discontinuation of therapy due to side effects was required in approximately 4% of patients treated with amlodipine besylate and benazepril hydrochloride and in 3% of patients treated with placebo.
Drugs that affect the renin-angiotensin system can cause hyperkalemia. Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5 mg to 10 mg while benazepril is effective in doses of 10 mg to 80 mg.
2002 Patients should be asked to report pregnancies to their physicians as soon as possible.Read this Patient Information leaflet before you start taking amlodipine besylate and benazepril hydrochloride capsules and each time you get a refill. The mechanism is not understood.
2004;24(11):641-9. doi: 10.2165/00044011-200424110-00003.
Although not currently recommended as first-line therapy, studies confirm that this combination of a long-acting calcium antagonist and an angiotensin-converting enzyme (ACE) inhibitor possesses substantial blood pressure lowering capabilities. Hypertensive patients treated with benazepril and amlodipine for up to 56 weeks had elevations of serum potassium up to 0.2 mEq/L [see Removal of angiotensin II negative feedback on renin secretion leads to increased plasma renin activity. Presumably due to the inhibition of the degradation of endogenous bradykinin, persistent nonproductive cough has been reported with all ACE inhibitors, generally resolving after discontinuation of therapy. Hypotension that occurs as a result of this mechanism can be corrected by volume expansion. Cough was the only adverse event with at least possible relationship to treatment that was more common on amlodipine besylate and benazepril hydrochloride (3.3%) than on placebo (0.2%). Benazepril is an ACE inhibitor.
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Similarly, the 5 mg/kg/day dose of benazepril is approximately twice the benazepril dose delivered when the maximum recommended dose of amlodipine besylate and benazepril hydrochloride is given to a 50 kg woman.
serious allergic reactions that can be life threatening. …
Amlodipine besylate and benazepril hydrochloride capsules, USP are indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent (Capsules (amlodipine mg/benazepril mg): 5 mg/40 mg, 10 mg/40 mg (Discontinuation because of adverse reactions occurred in 4% of amlodipine besylate and benazepril hydrochloride-treated patients and 3% of placebo-treated patients.
Changes in renal function, including acute renal failure, can be caused by drugs that affect the renin-angiotensin system.
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