Atorvastatin is a common option among the HMG‐CoA reductase inhibitors for the treatment of lipid disorders because of its excellent lipid‐lowering efficacy and overall safety profile.
Azithromycin kann oral oder intravenös angewendet werden. Adrenal Function .
However, it does not affect fluvastatin and rosuvastatin significantly [48,60].This review discussed clinically relevant interactions of statins with antibacterial and antifungal agents based on the pharmacokinetic properties of object and precipitant drugs, pharmacokinetic studies, observational studies, and manufacturer recommendations. Pulmonary Artery Stenosis.
Macrolide antibiotics are inhibitors of CYP3A4 and organic anion-transporting polypeptide-1B1.
The aim was to examine all reports including rhabdomyolysis‐azithromycin and statins in VigiBase to assess if the data were suggestive of an interaction.The individual case reports in VigiBase and the original files were reviewed.
Nonetheless, the AUC of most statins increases considerably despite not being metabolized by CYP450.
For daptomycin, systematic and manual searches identified four PK studies [21-24] and one [25] observational study, respectively.
Itraconazole and posaconazole are strong CYP3A4 inhibitors and mainly affect simvastatin, lovastatin, and atorvastatin, while fluconazole is an inhibitor of CYP2C9 and potentially CYP2C19 and mainly affects fluvastatin; however, risk cannot be ruled out with rosuvastatin.statin, antimicrobial, antibiotic, antifungal, drug interactionStatins (hydroxymethylglutaryl-CoA reductase inhibitors) are commonly used lipid-lowering medications that once started are typically administered for the life of the patient.
Case reports are suggestive of a drug interaction between statins and azithromycin with rhabdomyolysis.
In other studies, concomitant administration of rifampin decreased the AUC of simvastatin acid, pravastatin, fluvastatin, and pitavastatin by 90%, 50%, 30%, and 30% respectively [9.11,30,31].
Makrolide passieren die Plazenta und gehen auf den Feten über.
Effects of Atorvastatin . Medikament/Wirkstoff wählen oder Suchbegriff eingeben Genetic Association .
Makrolide passieren die Plazenta und gehen auf den Feten über.
The results also showed that reviewing spontaneous reports can add information to drug interactions not established previously.In general, 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) are well tolerated by most users The WHO Collaborating Centre for International Drug Monitoring, the Uppsala Monitoring Centre (UMC), based in Uppsala, Sweden, collects spontaneously reported cases of suspected ADRs. However, there was no reduction in atorvastatin AUC with simultaneous administration of rifampin, which is why the manufacturer recommends simultaneous rather than delayed administration of atorvastatin after rifampin administration [6]. These data suggest that while azithromycin appears to be safe to coadminister with atorvastatin, clarithromycin should be …
Numerous statins are substrates of CYP450, organic anion-transporting polypeptide (OATP)-1B1/3, and other transporters and metabolizing enzymes [3-5]. The case reports within the database originated from more than one country. Given that most people receive antimicrobial agents during their lifetimes, the co-administration of statins and antimicrobial agents is common. We review and highlight major drug-drug interactions between statins and antibacterial and antifungal agents; interactions with antiviral agents were not considered.
In a population-based cohort of older adults, concomitant administration of clarithromycin and/or erythromycin with statins was associated with a higher risk of adverse events compared to concomitant administration of azithromycin with statins [13,14].Clarithromycin increase the AUC of atorvastatin by up to 3.5 times its original value, while erythromycin increases it by 1.3 times its original value [15-17]. 9 Kontraindikationen.
Multiple doses of rifampin induce cytochrome P450 (CYP), particularly 3A4 and 2C9, resulting in reduced systemic exposures to all statins, except rosuvastatin, for which the response was variable.
Pharmacokinetic as well as pharmacodynamic interactions may be involved In conclusion, our study has demonstrated the usefulness of the newly developed disproportionality measure, Omega, in order to identify drug interactions in spontaneous reporting datasets. In vivo, it is reported to cause rhabdomyolysis with lovastatin, simvastatin, atorvastatin, and cervistatin.
Azithromycin has the fewest drug interactions, while clarithromycin and erythromycin increase systemic exposure to all statins except rosuvastatin and fluvastatin.
Antiviral agents were excluded from this study.There are various mechanisms by which statins can interact with other medications.
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