TD treatment was associated with reductions in the risks of CVs (odds ratio (OR): 0.86, This study suggests that use of TD in hypertensive patients results in a reduction in the risk of CVs. Three trials were excluded due to either low number of participants (Search flow diagram for studies included in the meta-analysis.Search flow diagram for studies included in the meta-analysis.Two investigators (Peng Chen and Sandip Chaugai) independently performed literature search and data extraction according to prespecified inclusion/exclusion criteria, and compared the results.
However, the beneficial effects are mainly confined to thiazide-like diuretics with only a modest trend toward protection observed with thiazide-type diuretics, suggesting that thiazide-like diuretics offer greater cardioprotection. All rights reserved. However, your doctor will tailor your drug regimen to your specific health concerns.

© 2005-2020 Healthline Media a Red Ventures Company. (However, a type of diuretic called a loop diuretic is more commonly used to treat heart failure.) And no significant differences were found in CHD (OR: 0.95, 95% CI: 0.85–1.06, Three trials were excluded from analysis of heart failure because they did not report the events of heart failure. Your doctor may advise you to take a potassium supplement or to eat foods rich in the nutrient to combat low potassium levels. For details see our Our clinical information is certified to meet NHS England's Information Standard.Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals.© Patient Platform Limited. Considering the high prevalence of hypertension globally, widespread use of thiazide-like diuretics may be expected to improve clinical outcomes and optimize the cost of care. DOI: 10.1002/14651858.CD001841.pub3We use cookies to improve your experience on our site. All rights reserved. They are often used to treat hypertension, or high blood pressure. They are occasionally also used for heart failure. Your kidneys are the filters through which toxins and excess fluids are flushed from your body. SHEP Cooperative Research GroupAHA/ACC/CDC Science Advisory: An Effective Approach to High Blood Pressure Control A Science Advisory From the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and PreventionManagement of high blood pressure in Blacks: an update of the International Society on Hypertension in Blacks consensus statementNICE hypertension guideline 2011: evidence based evolution© American Journal of Hypertension, Ltd 2015. Your specific medication may contain more than one type of diuretic agent in a single pill or dose.Diuretics are generally safe for most people when taken as prescribed.The most common side effect of diuretics is increased urination. Search for other works by this author on: Sandip Chaugai helped collect and identify literatures, re-analysis and finished paper editing.
Fujie Zhao helped paper screening and data analysis and Dao Wen Wang is corresponding author who assigned the project, supervised to finish each step and made final editing for the manuscript.Oxford University Press is a department of the University of Oxford. Application of alternative antihypertensive drug as step 1 drug in both TD and control arms of the trial were considered eligible for inclusion.Trials enrolling specialized patient populations such as post stroke, coronary heart disease (CHD), heart failure, or post-cardiac surgery, post hoc and subgroup analysis, trials not reporting the outcomes of interest, trials with <100 participants or <10 CV events or follow-up duration <1 year.

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