31, No. In assessing, for example, the effects of treatment on cognitive functioning, the POMS confusion factor and Mini-Mental State scores were examined in addition to performance on the digit symbol substitution and the shopping list tasks. An ANCOVA model that used baseline as a covariate and that included treatment, center, and the center-by-treatment interaction found significantly greater improvement on the POMS total score and several of the POMS factor scores that began at week 2 for the patients treated with sertraline. Although it is long known that the tricyclic antidepressants amitriptyline, nortriptyline and imipramine inhibit the noradrenaline transporter and αAmitriptyline, nortriptyline and imipramine are much weaker antagonists of rat and human αWe use cookies to help provide and enhance our service and tailor content and ads. 4The American Journal of Geriatric Psychiatry, Vol. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. 31, No. The lack of cardio-acceleratory effects also distinguished sertraline treatment from treatment with nortriptyline. ‡ This symbol next to a receptor indicates that the corresponding peptide is the endogenous ligand with the highest known potency for the receptor in humans.
58, No. Patients underwent a full battery of investigator-rated assessments: the 24-item Hamilton depression scale Cognitive function was assessed by means of the digit symbol substitution subtest of the Wechsler Adult Intelligence Scale Safety assessments included weekly measurements of pulse and blood pressure (sitting and standing) and a review of adverse effects and concomitant medications. 10Human Psychopharmacology: Clinical and Experimental, Vol. 2The American Journal of Geriatric Psychiatry, Vol. A second possible weakness may have been introduced by not adjusting nortriptyline doses according to plasma level determinations, which would have required burdensome design complexity to maintain the blind. 4The American Journal of Geriatric Psychiatry, Vol. A double-dummy procedure was used to preserve the blind.Nortriptyline was initiated at a dose of 25 mg in the evening and could be titrated in increments of 25 mg per week to a maximal daily dose of 100 mg. 5The American Journal of Geriatric Psychiatry, Vol. Find out what is the full meaning of HCL on Abbreviations.com! Address reprint requests to Dr. Bondareff, Department of Psychiatry, Division of Geriatric Psychiatry, USC School of Medicine, 1237 North Mission Rd., MOL 202, Los Angeles, CA 90033; 15, No. 37, No. Finally, adverse events were assessed by means of an open-ended inquiry.Blood samples (10 ml) were collected in heparinized Vacutainer tubes for monitoring of plasma drug concentration on day 1 of the placebo washout period and after 1, 3, 6, and 12 weeks of double-blind treatment. Treatment effects on the associated symptoms of insomnia were examined with the Hamilton depression scale sleep factor. 16, No. 15, No. 1214 April 2010 | Cochrane Database of Systematic Reviews, Vol. At week 12, 72.4% (N=55 of 76; 95% CI=61.0%–82.0%) of sertraline-treated patients and 61.4% (N=43 of 70; 95% CI=49%–73%) of nortriptyline-treated patients had responded (To test whether nortriptyline or sertraline might differ in antidepressant efficacy among patients with high depression severity at baseline (defined as a Hamilton depression scale total score >26), we performed a two-way ANOVA that compared the week 12 changes from baseline in Hamilton depression scale total score and CGI severity score as well as the week 12 CGI improvement score. Abstract.
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