While the mean treatment difference was maintained throughout the study, the effect size decreased over the course of the study, most likely because of increased variability (This study specifically investigated divalproex combination treatment in patients with acute exacerbation of schizophrenia. It’s important not to discontinue use of the drug if you feel better. Furthermore, over the 28-day course of this trial, combination therapy with divalproex was as well tolerated as antipsychotic monotherapy. Treatment differences (combination therapy Comparisons of the combination and monotherapy groups were made for mean trough total valproic acid plasma concentrations using a mixed effects model (with effects for treatment group, visit, treatment group by visit interaction, study center, age, and weight).Treatment differences in the percentage of patients who were granted hospital leave and the percentage of patients using adjunctive medication were assessed by Fisher's exact test.

Volk D, Austin M, Pierri J, Sampson A, Lewis D (2001). Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment.

So, the indication for which the drug is given is very important. Statistically significant treatment differences favoring the combination therapy group were noted at several evaluation points for BPRSd total (days 3, 5, 7, 10, and 14), positive symptoms (days 3, 5, and 7), and agitation (days 7 and 14) scores. Early improvement in symptoms of psychosis is important in the acute management and stabilization of patients with schizophrenia. Eiris JM, Lojo S, Del Rio MC, Novo I, Bravo M, Pavon P (1995). The interaction between GABA and dopamine: Implications for schizophrenia. Wassef AA, Dott SG, Harris A, Brown A, O'Boyle M, Meyer III WJ (2000).

These included two patients each in the olanzapine group (because of abnormal liver function tests results and asthma), the divalproex plus olanzapine group (hyperglycemia and rash) and the divalproex plus risperidone group (dyspepsia and flank pain (muscle strain offered as a likely etiology for the latter)) and one patient in the risperidone group (somnolence and hypotension).There were no treatment group differences for overall incidence of treatment-emergent adverse events (Seven patients reported a serious adverse event, all of which were judged by the investigators to be not related or probably not related to the study drug. Meltzer HY, Dai J, Ichikawa J (2001). The benefits of combination therapy with divalproex and either olanzapine or risperidone seem unlikely to be attributable to a simple pharmacokinetic interaction. In the meantime, to ensure continued support, we are displaying the site without styles Seven patients discontinued the study prematurely because of treatment-emergent adverse events; premature discontinuation rates were similar among the treatment groups. Before you take Risperdal, talk to your doctor if you are pregnant, planning to become pregnant, or are nursing. For statistical testing, race was categorized as Caucasian and non-Caucasian.

Of the 249 enrolled patients, 242 patients were included in the intent-to-treat analyses of efficacy, with 4 excluded because they did not have an on-treatment PANSS score and 3 excluded because they were randomized at two sites (only their second randomization was excluded from the efficacy analyses).The treatment groups were similar at baseline based on demography, schizophrenia subtype, age at first diagnosis, number of past hospitalizations, and the number of suicide attempts (A total of 83 (33%) patients prematurely discontinued their participation in the study, the most common reason being consent withdrawn (25 (20%) patients given antipsychotic monotherapy and 12 (10%) patients given combination therapy, The frequency with which patients left the hospital during the study was similar among the treatment groups. This combination may cause skin rash, restlessness, seizures, tremors, muscle weakness, and staggering walk. Chloral hydrate (up to 2 g/day) or zolpidem tartrate (up to 10 mg/day) could be used for the control of insomnia. Divalproex sodium augmentation of haloperidol in hospitalized patients with schizophrenia: Clinical and economic implications. Neurochemical correlates of cortical GABAergic deficits in schizophrenia: Selective losses of calcium binding protein immunoreactivity. Extrapolation of the positive results of this study to the general population of patients with psychosis should be done with careful consideration.Finally, the results of this trial must be interpreted in the context of an acute (28 day) treatment trial. You can also search for this author in

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