Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Other drugs that have the same active ingredients (e.g. Take it with a full glass of water and don’t lie down for an hour. Alendronate should be taken with a full glass of water and the person taking alendronate should remain upright for at least 30 minutes after taking it. The following information includes only the average doses of this medicine.
You should also avoid foods, supplements and antacids containing calcium and vitamin D for at least 30 minutes after taking alendronate. The oral bioavailability of a 10-mg alendronate tablet, taken with plain water after an overnight fast and 2 hours before ingestion of the first food of the day, is 0.8 percent in women; when the drug is taken 30 or 60 minutes before breakfast, its oral bioavailability is reduced to approximately 0.5 percent.This tablet was also used in the three-year trials of alendronate in women with postmenopausal osteoporosis.Adverse effects occurred at various points during the three-year study period. Along with its needed effects, a … These 18 patients included 5 who had taken alendronate at bedtime or during the night. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. Alendronate was discontinued, and she recovered after treatment with omeprazole. This possibility is consistent with the observation that lesions were circumscribed, with normal mucosa proximal and distal to the involved area, in some of our patients, as well as similar observations in another report.On the basis of the analyses reported here, the dose instructions for alendronate were revised worldwide to indicate that it should be taken when the patient is arising for the day, as followsTo facilitate delivery to the stomach and thus reduce the potential for esophageal irritation patients should be instructed to swallow [alendronate] with a full glass of water (6–8 oz) and not to lie down for at least 30 minutes Previously, cautious use of alendronate was advised in patients with active upper gastrointestinal problems.In summary, alendronate can cause chemical esophagitis, including severe ulcerations in some patients. Alendronate can damage the stomach and esophagus, so don't lie down for at least 30 minutes after taking the drug. All cases of adverse effects, whether or not the reporters thought they were caused by the drug, are included in our analysis, as are cases first encountered during the follow-up of other reports. Epub 2009 Jun 16.Derendorf H, Heinrichs T, Reimers T, Lebert C, Brinkmann A.GMS Infect Dis. generic drugs) are not considered. The postulated pathophysiologic mechanisms were direct esophageal irritation, and possibly reflux of drug-containing gastric contents.Failure of the alendronate tablet to pass through the esophagus may result in prolonged local mucosal exposure to the drug. Aminobisphosphonates can irritate the upper gastrointestinal mucosa.We describe three patients who had severe esophagitis shortly after starting to take alendronate and also analyze adverse esophageal effects reported to Merck, the manufacturer, through postmarketing surveillance.As of March 5, 1996, alendronate had been prescribed for an estimated 475,000 patients worldwide, and 1213 reports of adverse effects had been received.
In 18 of 33 reports with adequate information on the patient's posture, it was stated that the patient had not remained upright for 30 minutes or more after taking the tablet. Free E-newsletter Subscribe to Housecall . Merck had received a total of 1213 reports of adverse effects (1121 in the United States), of which 199 were related to the esophagus.
Never take Fosamax at bedtime. Side Effects.
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