Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of ceftazidime may occur that usually Check with your health care professional if any of the following side effects Inflammation and pain occurred after IM administration.Phlebitis and thrombophlebitis occurred with IV administration.Approximately 5% of patients developed a positive Coombs test.Neurological sequelae occurred in patients with renal dysfunction who did not receive appropriate dose adjustments and included coma, convulsions, encephalopathy, myoclonia, and tremor.Anaphylaxis included bronchospasm, cardiopulmonary arrest, and/or 1.
Class II B is a degradation impurity with a non-β-lactam structure, including impurity G. It is the C-7 side chain of CAZ, may be easily absorbed but not transported and have hepatotoxicity.The molecular docking results suggest that the scaffold of CAZ and its impurities, the quaternary amine group on the C-3 position, and the carboxyl and amino groups on the C-7 position may form hydrogen bonds with GRM1A protein residues and lead to neurotoxic effects. This makes it easier absorbed. Glaxo Wellcome, Research Triangle Park, NC.
It may be absorbed by the intestinal tract and metabolized by liver drug enzymes and may have hepatotoxicity and genotoxicity. "Product Information. Ceftazidime for injection, USP in sterile crystalline form is supplied in single-dose vials equivalent to 1 g or 2 g of anhydrous ceftazidime. It is widely used to treat infections, including sensitive strains and severe infections. However, the toxic effects of impurity D could not be predicted due to the formation of new toxic functional groups. Applies to ceftazidime: injectable powder for injection, intravenous powder for injection, intravenous solution. * Where associated with, or suspected to be associated with, any of the infections listed in section 4.1. The geometric optimization and thermochemistry calculations were performed by the ORCA 3.0.3 programThe DS4.0 software package was used for docking studies of selected targets and ligands. Furthermore, the bladder of the larvae (5 dpf) was small or absent, most larvae had delayed reaction to tail touch and showed less swimming (The structure of impurities F and G are similar to the C-3 and C-7 side chains of CAZ, respectively.
This can induce acute toxic effects for the E-isomer that are bigger than the original drug (Rule 8: Cephalosporins with MTT at C-3 position and the C-3 side chains are usually folded. Prediction of the structural alerts of genotoxicity also showed that the genotoxicity of CAZ and its impurities were mainly related to aromatic amine groups. Compared with impurity H, tertiary methyl butyl ester has stronger hydrophobicity and weaker molecular polarity, but its toxic functional group may be similar with impurity H. The toxic effect of impurity E may be stronger than impurity H.The 3D structure of impurity D reveals that the derivation of amino group at the C-7 position forms a new toxic functional group; however, the toxic functional group at the C-3 position is similar to CAZ.
The extended side chain may appear toxic at first—especially at low concentrations (Rule 3: The degradation of cephalosporins can lead to new toxic functional groups with different toxic effects (Rule 4: Toxic effects of drugs are determined by the characteristics of toxic functional groups and the absorption characteristics of the compounds. They can also be regarded as synthetic precursors of CAZ.
Ceftazidime is an antibiotic belonging to the group of third generation cephalosporins, frequently used in clinical practice for its broad antibacterial spectrum. Therefore, the toxicity of impurity H may be similar to CAZ, but the toxic effect is stronger.
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