These studies revealed no evidence of fetal harm. Select one or more newsletters to continue. Store at controlled room temperature 20 ° to 25 ° C (68 ° to 77 ° F); excursions permitted between 15 ° to 30 ° C (59 ° to 86 ° F). Clindamycin Phosphate Topical Gel, 1%, a topical antibiotic, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram in a gel vehicle consisting of carbomer 941, methylparaben, polyethylene glycol 400, propylene glycol, purified water, and sodium hydroxide. Discard after single use.Keep all liquid dosage forms in containers tightly closed.Clindamycin phosphate topical solution containing clindamycin phosphate equivalent to 10 mg clindamycin per milliliter is available in the following sizes:Clindamycin phosphate topical gel containing clindamycin phosphate equivalent to 10 mg clindamycin per gram is available in the following sizes:Clindamycin phosphate topical lotion containing clindamycin phosphate equivalent to 10 mg clindamycin per milliliter is available in the following size:Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP].This product's label may have been updated. I used clindamycin phosphate 1% GEL (on a clean face) and I got a rash on my face quickly. No significant increase in tumors was noted in the treated animals.A 1% clindamycin phosphate gel similar to Clindamycin Phosphate Topical Gel caused a statistically significant shortening of the median time to tumor onset in a study in hairless mice in which tumors were induced by exposure to simulated sunlight.Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion test. I would change this to 5 stars if the gel was in it's original formula. Use of the topical formulation of clindamycin results in absorption of theantibiotic from the skin surface. When significant diarrhea occurs, the drug should be discontinued. Each clindamycin phosphate topical solution pledget applicator contains approximately 1 mL of topical solution. We comply with the HONcode standard for trustworthy health information - Clindamycin phosphate topical gel contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Orally and parenterally administered clindamycin has been associated with severe colitis which may result in patient death. (see Apply a thin film of clindamycin phosphate topical solution, clindamycin phosphate topical lotion, clindamycin phosphate topical gel, or use a clindamycin phosphate topical solution pledget for the application of clindamycin phosphate twice daily to affected area. In view of the potential for diarrhea, bloody diarrhea, and pseudomembranous colitis, the physician should consider whether other agents are more appropriate. 59762-3728-3, Clindamycin is bacteriostatic.Resistance to clindamycin is most often caused by modification of specific bases of the 23S ribosomal RNA. The solution has an unpleasant taste and caution should be exercised when applying medication around the mouth.Clindamycin phosphate topical products should be prescribed with caution in atopic individuals.Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. In a contact sensitization study, four of the 200 subjects appeared to develop suggestive evidence of allergic contact sensitization to Clindamycin Phosphate Topical Gel. Clindamycin phosphate topical gel contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Manufactured for: However, orally and parenterally administered clindamycin has been reported to appear in breast milk. February 26, 2020 Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7 (S)-chloro-substitution of the 7 (R) … Antiperistaltic agents, such as opiates and diphenoxylate with atropine, may prolong and/or worsen the condition.Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of oral and parenteral therapy with clindamycinGeneral: Clindamycin Phosphate Topical Gel should be prescribed with caution in atopic individuals.Drug Interactions: Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. 59762-3728-2, In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), bathe with copious amounts of cool tap water. There are no adequate studies in pregnant women during the first trimester of pregnancy. The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus.
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