Methotrexate is an antimetabolite that blocks the synthesis. Patients with moderate or severe steatohepatitis (as established by ultrasonography of the liver) were excluded.
It was 7.0±0.38 in the methotrexate group and 7.8±0.29 in the cyclosporine group (absolute difference, 0.9; 95 percent confidence interval, –0.03 to 1.9; P=0.06).The total number of reported side effects was 113 in the methotrexate group and 166 in the cyclosporine group; side effects were reported by 29 and 35 patients in the two groups, respectively.
Quality-of-life scores were not significantly different in the two groups.The authors conclude that methotrexate and cyclosporine have similar efficacy in the treatment of widespread psoriasis and are tolerated equally well. ), Academic Medical Center, University of Amsterdam, Amsterdam.Address reprint requests to Dr. de Rie at the Department of Dermatology, Rm. After 16 weeks of treatment, the patients were monitored for another 36 weeks. Treatment was discontinued in one patient in the cyclosporine group because of an elevation in the bilirubin level (total bilirubin, 44 mg per deciliter [760 μmol per liter]) and icterus suggestive of the presence of Gilbert's syndrome (idiopathic hyperbilirubinemia).
Heydendael and colleagues report on a comparative trial of the safety and efficacy of methotrexate versus cyclosporine for widespread psoriasis.This study enrolled adult patients with moderate to severe psoriasis who had not responded well to treatment with ultraviolet B radiation and had not yet tried the study agents.
Methotrexate Use in Psoriasis. Our results of the effectiveness of cyclosporine are in agreement with those of earlier studies.Overall, the tolerability of both drugs was good.
We conduced a randomized, controlled trial comparing methotrexate and cyclosporine in terms of effectiveness, side effects, and the quality of life.A total of 88 patients with moderate-to-severe psoriasis were randomly assigned to treatment for 16 weeks with either methotrexate (44 patients; initial dose, 15 mg per week) or cyclosporine (44 patients; initial dose, 3 mg per kilogram of body weight per day) and were followed for another 36 weeks.
Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services.Methotrexate and cyclosporine are well-known systemic therapies for moderate-to-severe chronic plaque psoriasis. We used all available outcome data for patients.
Randomization was performed centrally with the use of computer-generated random numbers and block size of eight patients.
Two-sided P values of less than 0.05 were considered to indicate statistical significance.Scores for the psoriasis area-and-severity index (PASI) range from 0 (no disease) to 72 (the most severe disease possible).Between October 1998 and June 2000, 111 patients were screened, 88 of whom underwent randomization (Treatment had to be discontinued in 12 patients in the methotrexate group because of elevated liver enzyme levels (the highest level measured was an alanine aminotransferase level of 198 U per liter).
After four weeks, the study drug was increased in patients with less than a 25 percent reduction in psoriasis severity scoring. et al. Suppresses the immune system. A0-222, Academic Medical Center, University of Amsterdam, P.O.
Differences between the treatments in terms of side effects, long-term adverse effects, ease of administration (once-daily vs. twice-daily treatment), and costs can be used to guide treatment decisions in individual cases.Supported by a grant (OG 97-009) from the Dutch Health Authorities.We are indebted to the patients who participated in the study; to Leonard Witkamp, M.D., Ph.D., for the idea for this study; to Gabriëlle A.M. Appel, Fridolijn Langenhuijsen-Jongevos, M.D., Femke M.C. Complete remission of psoriasis was also similar between the two groups (40 percent of methotrexate patients and 33 percent of cyclosporine patients).
Sep 8, 2020 Though biologics are typically reserved for … Dropout before initiation of treatment was higher in the ciclosporin group.
Ziprasidone Interactions Lamisil, Wellbutrin SR Doses Lasuna, Muscle Relaxant Drugs Over The Counter Aciclovir, Terazosin Vs Tamsulosin Herbal Max Gun Power, Where Can I Buy Albendazole In Canada Vermox, Yasmin Mogahed Biography, Cure For Neuropathy After Chemo Mellaril, Himalaya Immunity Booster Feldene, Macular Degeneration Foods Not To Eat Malegra Dxt, Anastrozole And Weight Gain Isoptin, Is Letrozole Hair Loss Permanent Zetia, VigRX Plus Original Zofran, Pictures Of Amoxicillin Capsules Cleocin Gel, Chloramphenicol Slideshare Strattera, Style Edit Root Touch Up Black/dark Brown Minomycin, Himalaya Cough Syrup Remeron, What Can You Not Take With Tamoxifen Tulasi, Kaiser Permanentedesloratadine 5 Mg Tablet | Drug Encyclopedia | Kaiser Permanente Arcoxia, Calcitriol For Dogs Cost Avodart, Gaviscon And Sertraline Nortriptyline, Insulin Glargine Contraindications Speman, Why Do Nails Turn Black During Chemo Femcare,
