Patients with moderate to severe AD dementia were consecutively enrolled and randomized into three groups; groups 1 and 2 are dose-titration groups during the first 4 weeks using two different titration methods, and group 3 is no-titration group with direct escalation to 23-mg donepezil. Peak … 2014 Aug;39(4):334-42. doi: 10.1111/jcpt.12167. Micardis HCT is not intended as first-line therapy; individual titration of the separate components is needed.
YJH and JHL drafted the manuscript. Unable to load your collection due to an error High-dose donepezil is currently prescribed for patients with Alzheimer’s disease (AD) who showed poor or waning response to a lower dose at the risk of increasing cholinergic side effects.
Although we could not give a definitive answer to that because there was no statistically significant AE differences between group 1 and group 2, group 1 showed a numerical trend towards fewer TEAEs, fewer dropout rates due to AEs, and fewer moderate to severe AEs, suggesting that 15 mg/day dose-titration might be preferable than alternate dose titration (group 2). Using safety population (In this study, dose titration before escalating to donepezil 23 mg/day showed better safety in terms of cholinergic AEs. In addition, we only included Korean patients with moderate to severe AD. Epub 2009 Sep 30.Cochrane Database Syst Rev. We included patients with moderate to severe AD who were treated with a stable dose of donepezil 10 mg/day. Wiley First, the sample size was relatively small. donepezil donepezil ODT memantine pyridostigmine pyridostigmine ER rivastigmine Mestinon syrup Namenda titration pack Mestinon tablet Namenda Namenda XR Namenda XR titration pack (QL) Namzaric (QL) Regonol ANXIETY/DEPRESSION/BIPOLAR DISORDER alprazolam alprazolam ER alprazolam intensol alprazolam ODT alprazolam XR … Cholinergic side effects particularly nausea, and possibly dizziness and headache, were fewer in dose-titration groups compared with no-titration group. The study was conducted in accordance with the Declaration of Helsinki and principles of Good Clinical Practice.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. High-dose donepezil is currently prescribed for patients with Alzheimer’s disease (AD) who showed poor or waning response to a lower dose at the risk of increasing cholinergic side effects. Relationships between the study drug and AEs were rated as unrelated, possibly related, or probably related: AEs clearly not related to the study drug were considered to be unrelated, AEs which follow a reasonable temporal sequence from initiation of the study drug but could be caused by other factors were considered to be possibly related, and AEs which follow a reasonable temporal sequence from initiation of the study drug and confirmed by improvement on stopping the study drug and that could not reasonably explained by other known characteristics of the participant’s clinical status were considered to be probably related. J Nucl Med. Unable to load your delegates due to an error Our inclusion criteria were as follows: (1) age ranged between 45 and 90, (2) patients diagnosed with probable AD dementia according to the NIA-AA criteria [We divided patients into three groups according to the dose escalation method: 15 mg of donepezil for 4 weeks before escalating to 23 mg (group 1), 10 mg and 23 mg on alternate days for 4 weeks before escalating (group 2), and direct escalation to 23 mg (group 3).The study protocol and informed consent form were reviewed and approved by the institutional review board of each center.
2005;76:315–9.Sabbagh M, Cummings J. The results support the idea that dose titration during the first 4 weeks before escalating to 23 mg can avoid a sharp increase in peak concentration and confer benefits in safety and tolerability during the initially critical and the most risky period [Another interesting issue is which titration method would be better regarding patient’s safety and tolerability.
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