doi: 10.1111/j.1600-079x.1998.tb00390.x. Varayoud J, Ramos JG, Monje L, Bosquiazzo V, Muñoz-de-Toro M, Luque EH.J Endocrinol. 2018 Jun 23;16(1):62. doi: 10.1186/s12958-018-0375-5.Neurosci Biobehav Rev. Epub 2019 Jul 22.Chuffa LG, Lupi-Júnior LA, Costa AB, Amorim JP, Seiva FR.Steroids. Its growth inhibitory actions have been thought to be linked to the estrogen-receptor system. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2005 Jul;186(1):51-60. doi: 10.1677/joe.1.06099.Biochem Biophys Res Commun. We tested the cytotoxic effects of melatonin on MCF-7 and T47D human breast cancer cell lines by using the SRB (sulforhodamine-B), XTT-tetrazolium, and bromodeoxyuridine (BrdU) assays in 96-well microtiter plates. The daily treatment thus resulted in persistently high circulating levels of melatonin for 14 days. blurred vision. 2015 Dec 5;417:1-9. doi: 10.1016/j.mce.2015.09.001. Melatonin inhibits the enzymes involved in the synthesis of estrogen, thus leads to lower levels of estrogens. It is thus considered to be a selective estrogen enzyme modulator. HT, added in combination with melatonin, reduced ERα levels back to control levels, but PR levels remained elevated albeit intermediary to those achieved with melatonin alone. 1992 Jul 10;64(3):249-56. doi: 10.1016/0304-3835(92)90050-6.Front Neuroendocrinol. 2019 Jul 9;9:525. doi: 10.3389/fonc.2019.00525. Elsevier Science Epub 2016 Dec 29.Dodda BR, Bondi CD, Hasan M, Clafshenkel WP, Gallagher KM, Kotlarczyk MP, Sethi S, Buszko E, Latimer JJ, Cline JM, Witt-Enderby PA, Davis VL.Front Oncol. Epub 2017 Oct 13.Ma Y, Guo H, Zhang L, Tao L, Yin A, Liu Z, Li Y, Dong H, Xiong L, Hou W.Sci Rep. 2016 Feb 19;6:21467. doi: 10.1038/srep21467. 2000 Apr;21(2):133-70. doi: 10.1006/frne.1999.0194.Mol Cell Endocrinol. Name must be less than 100 characters 2015 Oct;26(10):1501-6. doi: 10.1007/s10552-015-0640-2. The pineal hormone melatonin has been reported to have in vitro antiproliferative effects on estrogen receptor-positive human breast cancer cell lines at concentrations near to plasma physiological concentrations (1 x 10(-11) to 1 x 10(-9) M). 2018 Aug;99(4):158-171. doi: 10.1111/iep.12283.Qi S, Yan L, Liu Z, Mu YL, Li M, Zhao X, Chen ZJ, Zhang H.Reprod Biol Endocrinol. 2018 Jan;84:35-48. doi: 10.1016/j.neubiorev.2017.10.011. The Mayo Clinic reports that alterations in the levels of these hormones affect the process of ovulation and menstruation, which can cause problems with conceiving or maintaining a pregnancy. Please enable it to take advantage of the complete set of features! Melatonin significantly increased uterine estrogen receptor alpha (ERα) and progesterone receptor A levels compared to control animals. eCollection 2019.de Souza BR, de Almeida Chuffa LG, Simão VA, Camargo ICC.Int J Exp Pathol. doi: 10.1111/j.1600-079x.1998.tb00390.x. iv) Melatonin is also seen to be involved in the metabolism of estrogen, transforming estradiol into its inactive estrogen sulphate/sulfate form. Wiley Intracellular glutathione levels did not seem to play any role in the sensitivity of breast cancer cells to melatonin, since the addition of L-buthionine-[S,R]-sulfoximine, ethacrynic acid, or exogenous glutathione did not modify our results. 2017 Feb;118:93-108. doi: 10.1016/j.steroids.2016.12.011. Clipboard, Search History, and several other advanced features are temporarily unavailable. Back, leg, or stomach pains. We conclude that under our experimental conditions melatonin has no inhibitory effects on human breast cancer cells at low (physiological or supraphysiological) concentrations. There’s not a lot of evidence that taking melatonin, even at high levels, causes any harmful, dangerous, or long-term side effects.But some side effects have been documented.
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