However, Tamoxifen stimulates the estrogen receptors in the lining of the uterus so it acts like an estrogen and can cause endometrial hyperplasia. Currently, it is under study inchemoprevention trials in healthy women at high risk for breast cancer.Although tamoxifen acts against breast cancer primarily as an antiestrogen,the agent also possesses partial estrogen agonist activity. Cohen I, Tepper R, Rosen DJD, et al: Continuous tamoxifen treatmentin asymptomatic postmenopausal breast cancer patients does not cause aggravationof endometrial pathologies. Tamoxifenpatients have increased endometrial thickness on ultrasound; if the abnormalcut-off point was set at five mm, about half of patients would undergoneedless endometrial sampling.
Gibson LE, Barakat RR, Venkatraman ES, et al: Endometrial pathologyat dilatation and curettage in breast cancer patients: Comparison of tamoxifenusers and nonusers.
There appears to be a possible role for transvaginal sonography;however, a cut-off point for abnormal endometrial thickness needs to becarefully chosen.
This risk occurs because of the way tamoxifen works: Even as it acts against the growth-promoting effects of the female hormone estrogen in breast tissue, … It binds to the estrogen receptor and is used primarily for adjuvant therapy in breast cancer. Tamoxifen itself produces gynecologic symptoms that lead toincreased intervention, and thus a detection bias may result. Kedar RP, Bourne TH, Powles TJ, et al: Effects of tamoxifen on uterusand ovaries of postmenopausal women in a randomised breast cancer preventiontrial.
Clipboard, Search History, and several other advanced features are temporarily unavailable. doi: 10.1016/s0301-2115(00)00376-6. Endometrial thickness, as evaluated by vaginal ultrasonography, and endometrial histologic findings, as well as demographic characteristics, health habits, and risk factors for endometrial cancer, were compared between 93 asymptomatic postmenopausal breast cancer patients who had been on tamoxifen treatment and 20 patients who had not.
A more appropriate cut-off point might be more thaneight mm, as this was 100% predictive of discovering atypical hyperplasiaor endometrial polyps in one study. The rate of endometrial cancer was the lowest in the aromatase inhibitor only group (0.95/1,000 person-years), followed by the no endocrine therapy group (0.98/1,000 person-years). This site needs JavaScript to work properly. Has anyone had to have their uterus scrapped due to thickening of the lining? The 11% incidence of endo- metrial cancer reported in this studyfor symptomatic women is similar to that seen in women with postmenopausalbleeding in the general population. 2015 Jan;398(1-2):21-30. doi: 10.1007/s11010-014-2201-5. However, it can also act as a pro-estrogen agonist in a low estradiol environment. 2. doi: 10.1016/s0301-2115(00)00376-6. Moreover,an increase in the hyperdiploid fraction in endometrial biopsies--a markerfor endometrial proliferation--has been associated with the duration oftamoxifen use. [ONCOLOGY 11(Suppl 1):35-37, 1997]Tamoxifen (Nolvadex) is currently the first-line endocrine therapy forbreast cancer. 2000 Dec;11(12):1537-43. doi: 10.1093/oxfordjournals.annonc.a010406.Jones ME, van Leeuwen FE, Hoogendoorn WE, Mourits MJ, Hollema H, van Boven H, Press MF, Bernstein L, Swerdlow AJ.Breast Cancer Res. Patients were not stratified as to the presence ofuterine fibroids.
It binds to the estrogen receptor and is used primarily for adjuvant therapy in breast cancer. 2004;3(3-4):265-81. doi: 10.1007/s10689-004-9554-y.
United Healthcare Coronavirus Prandin, Soy Isoflavones Capsules Lotrisone, Himalaya Herbals Anti-dandruff Hair Cream Claritin, Zandopa Patanjali Levitra With Dapoxetine, Ointment For Hair Growth Robaxin, Can I Take Tylenol With Enalapril Augmentin, Clenbuterol Price Revia, Atralin Gel Buy Online Sustiva, Fiduciaria Davivienda Shallaki, Average Cost Of Prescription Drugs In Canada Tetracycline, Anti Stress Tablets Himalaya Brand Temovate, Best Medicine For Ringworm Viagra Jelly, Hair Dust Powder Karela, Jason Nash Is Married Box Office Malegra Dxt, Grisi Sulfur Soap Scabies Super Force Jelly, Ciudad Guabinas Innopran Xl, Gluconorm Dosage Myambutol, Paracetamol Untuk Ibu Hamil Metformin, Dasatinib Lariam, Emu Oil Shampoo Hair Loss Lozol, Does Tylenol Raise Blood Pressure Tadora, Dog Ate Lamisil, Cabergoline Interactions Prograf, Is Imitrex An Nsaid, Why Celecoxib Is Banned Esidrix, Ankylosing Spondylitis Immunosuppressive Drug Furadantin, Mefloquine Syndrome Volume Pills,
