2010 Authors Laura Galatti, Antonio Fioravanti, Francesco Salvo, Giovanni Polimeni, Saffi E Giustini. Congestive Heart Failure, Cardiac Effects and Drug Interactions.

Interaction between tadalafil and itraconazole. BRAND NAME(S): Sporanox. ", keywords = "CYP3A4, Cytochrome P450, Dosage regimen, Drug interaction, Time-dependent inhibition", author = "A. Toi and H. Ohtani and M. Tsujimoto and Y. Sawada", journal = "International Journal of Clinical Pharmacology and Therapeutics",

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The aim of this study was to identify an appropriate dosage schedule to avoid their interaction. Y1 - 2010/6.



title = "Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam", abstract = "Objective: Itraconazole is a potent inhibitor of cytochrome P450 (CYP) 3A with an elimination half-life of more than 30 hours. The developed model was simultaneously fitted to the plasma concentration profiles of triazolam, taken fromthe literature, by using the plasma concentration-time profiles of itraconazole and hydroxyitraconazole as input functions to estimate their in vivo Ki values.

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International Journal of Clinical Pharmacology and Therapeutics View full fingerprint This website also contains material copyrighted by 3rd parties. Conclusions: The developed model may provide useful information with regard to the appropriate interval for triazolam administration during itraconazole therapy. 2005 Jan;39(1):200. doi: 10.1345/aph.1E383. Although separating their dosages by 24 hours has been shown to reduce the interaction, an appropriate dosage interval remains to be determined. With conventional itraconazole preparations serum levels can vary greatly between patients, often resulting in serum concentrations lower than the therapeutic index.
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and formulary information changes. Triazolam is primarily metabolized by CYP3A and its plasma concentration is increased remarkably by itraconazole. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC.

Subsequently, we simulated the plasma concentration profiles of triazolam administered after itraconazole therapy with various dosing intervals.

BOXED WARNING. The developed model was simultaneously fitted to the plasma concentration profiles of triazolam, taken fromthe literature, by using the plasma concentration-time profiles of itraconazole and hydroxyitraconazole as input functions to estimate their in vivo Ki values.

By continuing you agree to the Objective: Itraconazole is a potent inhibitor of cytochrome P450 (CYP) 3A with an elimination half-life of more than 30 hours.



Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolamInternational Journal of Clinical Pharmacology and TherapeuticsPharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolamPharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolamInternational Journal of Clinical Pharmacology and TherapeuticsInternational Journal of Clinical Pharmacology and Therapeutics T1 - Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam. The study is created by eHealthMe based on reports of 3 people who take the same drugs from the Food and Drug Administration (FDA), and is updated regularly.



Affiliation 1 Repatriation General Hospital, Daw Park, South Australia.

Although separating their dosages by 24 hours has been shown to reduce the interaction, an appropriate dosage interval remains to be determined.

1077685-overview Conclusions: The developed model may provide useful information with regard to the appropriate interval for triazolam administration during itraconazole therapy.AB - Objective: Itraconazole is a potent inhibitor of cytochrome P450 (CYP) 3A with an elimination half-life of more than 30 hours.

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