V. De Campos, C. Cerqueira-Coutinho, F. Capella, B. Soares, C. Holandino and C. Mansur, Development and in vitro assessment of nanoemulsion for delivery of ketoconazole against 18.
A. M. Stewart, M. E. Grass, D. M. Mudie, M. M. Morgen, D. T. Friesen and D. T. Vodak, Development of a biorelevant, material-sparing membrane flux test for rapid screening of bioavailability-enhancing drug product formulations, 21. G. Balata, M. Mahdi and R. A. Bakera, Improvement of solubility and dissolution properties of ketoconazole by solid dispersions and inclusion complexes, 26.
Ketoconazole is very well soluble in DMSO. No formal evaluation of the effect of age on the pharmacokinetics of Ketoconazole HRA has been performed. Cmax and AUC increase more than proportionally with dose.
No recommendation on posology can be made for children under 12.
Ketoconazole HRA should not be administered when liver enzymes are greater than 2 times the upper limit of normal or in association with other hepatotoxic drugs. This site uses cookies. Maraviroc dose should be decreased to 150 mg twice daily.Contraindicated due to the risk of QT prolongation (see section 4.3).Careful monitoring.
Both ketoconazole and dipyridamole are weak bases with pK a values of (2.94, 6.15) and 6.4, respectively (10,11).
Not recommended due to the risk of QT interval prolongation and serious hepatic adverse reactions.Monitoring of QT-prolongation if used concomitantly. Volume 61 (2011)
Therefore, inhibitors of CYP3A4 may affect estrogen drug metabolism. Ketoconazole at doses of 40 mg/kg/day and higher produces evidence of embryotoxicity and teratogenicity in rats and rabbits.
Dose adjustment of risperidone may be required.Careful monitoring.
A review of concomitant medicinal products should be conducted when initiating ketoconazole treatment since ketoconazole is a known strong CYP3A4 inhibitor. T. Loftsson and E. Stefánsson, Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye, 25.
T. L. Rogers, K. A. Overhoff, P. Shah, P. Santiago, M. J. Yacaman, K. P. Johnston and R. O. Williams, Micronized powders of a poorly water soluble drug produced by a spray-freezing into liquid-emulsion process, 14.
Relationship between matrix structure and release kinetics, 11.
Ketoconazole is widely distributed into tissues; however, only a negligible proportion of ketoconazole reaches the cerebral-spinal fluid.Ketoconazole is extensively metabolised to a large number of inactive metabolites.
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