It is chemically designated as L-3,3',5,5'-tetraiodothyronine monosodium hydrate.
See full prescribing information for LEVOXYL.WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSSSee full prescribing information for complete boxed warning.Thyroid hormones, including LEVOXYL, should not be used for the treatment of obesity or for weight loss.Doses beyond the range of daily hormonal requirements may produce serious or even life-threatening manifestations of toxicity (Cardiac adverse reactions in the elderly and in patients with underlying cardiovascular disease:Acute adrenal crisis in patients with concomitant adrenal insufficiency:Prevention of hyperthyroidism or incomplete treatment of hypothyroidism:Decreased bone mineral density associated with thyroid hormone over-replacement:To report SUSPECTED ADVERSE REACTIONS, contact Pfizer, Inc. at 1-800-438-1985 or FDA at 1-800-FDA-1088 orThyroid hormones, including LEVOXYL, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss.In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction.Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects Pituitary Thyrotropin (Thyroid-Stimulating Hormone, TSH) SuppressionPrimary Hypothyroidism in Adults and in Adolescents in Whom Growth and Puberty Are CompletePediatric Dosage - Congenital or Acquired Hypothyroidism Table 1: LEVOXYL Dosing Guidelines for Pediatric HypothyroidismNewborns (0 to 3 months) at Risk for Cardiac FailureTSH Suppression in Well-Differentiated Thyroid CancerTable 2: Drugs That May Decrease T4 Absorption (Hypothyroidism)Table 3: Drugs That May Alter Thyroxine (T4) and Triiodothyronine (T3) Serum Transport Without Affecting Free Thyroxine (FT4) Concentration (Euthyroidism)Table 4: Drugs That May Alter Hepatic Metabolism of T4 (Hypothyroidism)Table 5: Drugs That May Decrease Conversion of T4 to T3Disease-Associated Maternal and/or Embryo/Fetal RiskDose Adjustments During Pregnancy and the Postpartum PeriodTable 7: Pharmacokinetic Parameters of Thyroid Hormones in Euthyroid PatientsWhat is the most important information I should know about LEVOXYL?Do not use LEVOXYL to treat weight problems or weight loss.Do not take more LEVOXYL than your healthcare provider prescribes for you to take.
Closely monitor blood pressure and heart rate in these patients.Concurrent use may of sympathomimetics and levothyroxine may increase the effects of sympathomimetics or thyroid hormone.
What is in this leaflet 1.
Over dosage or taking too much LEVOXYL may cause life-threatening side effects or death.Before you take LEVOXYL, tell your healthcare provider about all of your medical conditions, including if you:Tell your healthcare provider about all the medicines you take,Know the medicines that you take. 0000035331 00000 n Administration of sertraline in patients stabilized on LEVOXYL may result in increased LEVOXYL requirements.Concurrent use of ketamine and LEVOXYL may produce marked hypertension and tachycardia. Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with LEVOXYL LEVOXYL has a narrow therapeutic index.
(See full prescribing information for drugs that affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to LEVOXYL. WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSSThyroid hormones, including Levothyroxine Sodium Injection, should not be used for the treatment of obesity or for weight loss.Larger doses may produce serious or even life threatening manifestations of toxicity.
Levothyroxine Sodium Injection is in single dose clear glass vials.Thyroid hormones exert their physiologic actions through control of DNA transcription and protein synthesis.
These include urticaria, pruritus, skin rash, flushing, angioedema, various gastrointestinal symptoms (abdominal pain, nausea, vomiting, and diarrhea), fever, arthralgia, serum sickness and wheezing.
0000019153 00000 n The higher affinity of both TBG and TBPA for T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3.
Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.heart problems.
Levothyroxine sodium has an empirical formula of CLevothyroxine Sodium Injection is a sterile, preservative free, clear, colorless, sterile solution for intravenous administration available as: 100 mcg per 5 mL (20 mcg per mL), 200 mcg per 5 mL (40 mcg per mL), and 500 mcg per 5 mL (100 mcg per mL). Protein-bound thyroid hormones exist in reverse equilibrium with small amounts of free hormone. Select one or more newsletters to continue. The liver is the major site of degradation for both T4 and T3, with T4 deiodination also occurring at a number of additional sites, including the kidney and other tissues. 0000025872 00000 n Store dry product at controlled room temperature 15° to 30°C (59° to 86°F).
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