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Search for other works by this author on: Linezolid, an oxazolidinone antibacterial, is active against Gram-positive bacteria including meticillin-resistant Staphylococcus aureus (MRSA), and glycopeptide-resistant enterococci. Unadjusted Kaplan-Meier plot of thrombocytopenia among patients with and without renal impairment treated with linezolid in study 1. ), filters (membrane, surface, etc. Monte Carlo simulations were performed to identify linezolid dosing regimens that maximized attainment of therapeutic trough concentrations (2 to 8 mg/liter) across various renal-function groups. Comparison of treatment options in adults with frequently relapsing or steroid-dependent minimal change disease

Linezolid CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 600 mg twice daily PHARMACOKINETICS ; Molecular weight :337.3 %Protein binding :31 %Excreted unchanged in urine : 30; Volume of distribution (L/kg) :0.6; half-life – normal/ESRD (hrs) :5–7/Unchanged Thrombocytopenia occurs more frequently in patients with renal impairment receiving standard linezolid doses. REML analysis of mixed models, in

The difference between levels ‘with HD’ and those ‘without HD’ were examined by means of a mixed model for repeated measurements using the REML directive of the statistical software GenStat release 8.0 (VSN International Ltd, Waterhouse Street, Hemel Hempstead, UK) which allows the analysis of highly correlated and unbalanced data [ Population pharmacokinetics of multiple-dose regimen was estimated by fitting a two-compartment non-linear mixed-effect model with the package WinNonMix Version 2.0 (Pharsight Corporation, Cary, NC, USA).



Many factors can in fact profoundly alter the drug volume of distribution of the critically ill patient such as increased capillary leak, decreased plasma proteins, aggressive fluid resuscitation, altered haemodynamic status, organ dysfunction, complex drug–drug interactions [ Second, linezolid levels were lower in patients with higher body weight.


Trough serum linezolid levels averaged 5.83 mg/l (range 1.48–15.84), exceeding 4.0 mg/l in 68.9% of the samples; however, the trough levels ‘with HD’ were lower than those ‘without HD’ (4.68 mg/l [range 1.48–9.07] vs 6.74 mg/l [range 2.04–15.84], P <0.001). However, his data fully agree with the results we recently published in a single-dose study carried out on several patients, showing that fractional removal by a single haemodialysis session is about 32% of the last dose administered [ Sixth, our results cannot be extrapolated to intermittent renal replacement modalities based on different depurative mechanisms (convective or mixed convective and diffusive techniques, etc.


Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USADepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USADepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USACharles A. Peloquin, Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaDepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USADepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USADepartment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USACharles A. Peloquin, Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.Use the link below to share a full-text version of this article with your friends and colleagues. 2016 May;12(5):533-44. doi: 10.1517/17425255.2016.1166204. doi: 10.1128/AAC.00027-20.

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