2020;16(1):47–50 DOI: https://doi.org/10.17925/USE.2020.16.1.47

In BRC-treated GH3 cells, which do not have the D2R, apoptosis is induced and is closely associated with the activation of p38 MAPK. The next step in evaluating a patient with hyperprolactinemia is to perform imaging of the The molecular biology of idiopathic hyper-prolactinemia and lactotroph adenomas remains uncertain, but an area of research interest. False positive results can occur when the patient has heterophilic antibodies directed against the antibodies used in the assay system. 16 The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review.Dopamine agonists such as bromocriptine and cabergoline are the predominant treatment drugs for prolactinoma by inhibiting prolactin secretion and shrinking tumor size. The pituitary gland, or hypophysis, is the ‘master gland’ that secretes multiple hormones which regulate the functioning of other endocrine organs, such as the thyroid, adrenal cortex and gonads.
However, the pathways of either dopamine or its agonists that lead to the death of cells are incompletely understood and some are even conflicting conclusions. McCune–Albright syndrome (MAS) is a genetic disorder first described by McCune1 and Albright2  in the 1930s as a triad of polyostotic fibrous dysplasia, café-au-lait spots, and precocious puberty (Figure 1). Dopamine agonists (DAs), such as bromocriptine (BRC) and cabergoline (CAB) are the first-line drugs for the treatment of patients with idiopathic hyperprolactinemia and prolactinomas (3, 7). For patients who are resistant or not very responsive to BRC, CAB has been proven to be effective (The effect of CAB on reducing the size of prolactinomas is also mediated through the activation of the D2R (D2S) of anterior pituitary cells and is estrogen-dependent. 5.3 Preclinical safety data . The main aim of this paper is to review the different pathways of dopamine and its agonists in prolactinomas to help to gain a better understanding of their functions and drug resistance mechanisms.Pituitary adenomas (PAs) are common intracranial neoplasms. Pituitary Disorders Saptarshi Bhattacharya, Sanjay Kalra, Deep Dutta, Deepak Khandelwal, Rajiv Singla Bromocriptine is an ergot derivative with a short half-life slightly less than 3.5 hours, requiring two or three administration times daily. In the treatment of hyperprolactinemia it is superior to bromocriptine in terms of efficacy and tolerability (13– 15). Also, even though CAB and BRC are both dopamine agonists, the signal transduction pathways activated by the two drugs seem to be different. Iuliu Hațieganu University of Medicine and Pharmacy, RomaniaDepartment of Hypothalamic and Pituitary surgery, Toranomon Hospital, Japan Pre-clinical data for BROMOCRIPTINE (bromocriptine… 19, 20 It has been established as both safe and effective for the treatment of hyperprolactinemia. View all It is also better-tolerated and has fewer side effects.
One also wants to rule out the possibility of multiple endocrine neoplasia type-1 (MEN-1) by taking a thorough family history and obtaining calcium and phosphorous levels, as well as any other indicated blood tests. The two DA receptor families play different roles.

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