You can also search for this author in In our conditions, the detection limits for EThe excretion rate of 6-sulfatoximelatonin, a metabolite of melatonin, was taken as an indirect measure of the circulating levels of melatonin. Delagrange, Philippe
There were large interstitial spaces between the stromal cells and a great amount of collagen in the vicinity of the myometrium.Pinealectomized rats (GIII) had an increased size of the endometrial epithelial and stromal cells (The stromal morphology of melatonin-treated pinealectomized rats (group GIV, see Actions related to the process of reproduction represent the largest group of the spectrum of functions identified for melatonin in rodents: inhibitory regulation of GnRH; inhibition of gonadal development, spermatogenesis, and androgen production in males; and regulation of follicles, CL and interstitial tissue proliferation in female rats (Functional melatonin receptors in rat ovaries at various stages of the estrous cycle.17Beta-estradiol modulates hMT1 melatonin receptor function.Variations of MT1 melatonin receptor density in the rat uterus during decidualization, the estrous cycle and in response to exogenous steroid treatment.Functional melatonin receptors in rat ovaries at various stages of the estrous cycle.Variations of MT1 melatonin receptor density in the rat uterus during decidualization, the estrous cycle and in response to exogenous steroid treatment.The data presented herein show that, upon pinealectomy, the ensuing reduction of the circulating levels of melatonin lead to a proliferative response of the endometrium, an effect that was reversed by replacement therapy with melatonin.One explanation for the effects of this hormone on endometrium is a direct action through the coupling to specific melatonin receptors.
The mechanisms underlying this effect may be dual, namely, by directly acting on melatonin receptors or indirectly through a disturbance in ovarian steroids.Quantification of melatonin in phototrophic organisms.Human pineal physiology and functional significance of melatonin.The pineal gland: basic physiology and clinical implication.Evidence for melatonin in rodent Harderian gland: a dynamic in vitro study.Effects of melatonin the mediobasal hypothalamus on the secretion of gonadotropin in sheep: role of dopaminergic pathways.Circadian and seasonal control of neuroendocrine-gonadal activity.The neuroendocrine control of the ovarian cycle of the rat.Pinealectomy changes rat ovarian interstitial cell morphology and decreases progesterone receptor expression.Similarity between the effects of suprachiasmatic nuclei lesions and of pinealectomy on gonadotropin release in ovariectomized, sulpiride-treated and melatonin-replaced rats.Effects of pineal indoles on ovarian response to gonadotropin-induced ovulation in mice.Evaluation of the implantation in pinealectomized and/or submitted to the constant illumination rats.Functional melatonin receptors in rat ovaries at various stages of the estrous cycle.Measurement of melatonin and 6-sulphatoxymelatonin.Metoclopramide-induced hyperprolactinemia affects mouse endometrial morphology.Rat embryo quality and production efficiency are dependent on gonadotrophin dose in superovulatory treatments.Metoclopramide-induced hyperprolactinemia caused marked decline in pinopodes and pregnancy rates in mice.17Beta-estradiol modulates hMT1 melatonin receptor function.Variations of MT1 melatonin receptor density in the rat uterus during decidualization, the estrous cycle and in response to exogenous steroid treatment.In vitro modulation of steroidogenesis and gene expression by melatonin: a study with porcine antral follicles.Modulation of estrous cycle and LH, FSH and melatonin levels by pinealectomy and sham-pinealectomy in female rats.Effects of melatonin on the ovarian response to pinealectomy or continuous light in female rats: similarity with polycystic ovary syndrome.Physiological pineal effects on female reproductive function of laboratory rats: prenatal development of pups, litter size and estrous cycle in middle age.Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids.Endometrium estradiol receptors type I and type II during early pregnancy of rat.Mouse uterine glands during the peri-implantation period: fine structure.Glycodelin is present in pinopodes of receptive-phase human endometrium and is associated with down-regulation of progesterone receptor B.Received in revised form: After 1 week the males were placed in boxes with several females until at least three positive plugs were obtained. Alternatively, there may be some indirect effect through the ovarian hormonal production (Functional melatonin receptors in rat ovaries at various stages of the estrous cycle.In vitro modulation of steroidogenesis and gene expression by melatonin: a study with porcine antral follicles.Evaluation of the implantation in pinealectomized and/or submitted to the constant illumination rats.In contrast, the treatment of pinealectomized animals with melatonin increased the P production and the embryo implantation. Forcada, F
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