Pregnancy: Category B Lactation: No Human data – Probably Compatible.

Rheumatologic conditions: Acute gouty arthritis, ankylosing spondylitis, dermatomyositis/polymyositis, polymyalgia rheumatica, psoriatic arthritis, relapsing polychondritis, rheumatoid and juvenile arthritis, Sjogren’s syndrome, systemic lupus erythematosus, vasculitis ::: Unlabeled Uses: Autoimmune hepatitis; adjunctive therapy for pain management in immunocompetent patients with herpes zoster; Takayasu arteritis; giant cell arteritis; Grave’s ophthalmopathy prophylaxis; subacute thyroiditis; thyrotoxicosis (type II amiodarone-induced) High risk individuals include those with partners known to be HIV-1 infected or who engage in sexual activity within a high prevalence area or social network, and one or more of the following: - Inconsistent or no condom use - Diagnosis of sexually -transmitted infections - Exchange of sex for commodities - Use of illicit drugs or alcohol dependence - Incarceration - Partner of unknown HIV-1 status with any of the above risk factors | When prescribing PrEP health care providers MUST: - Include PrEP as part of a comprehensive prevention strategy because PrEP alone is not always effective in preventing HIV-1 infection - Counsel all uninfected patients to strictly adhere to the dosing schedule, because adherence was strongly correlated with effectiveness in clinical trials - Confirm a negative HIV-1 test prior to starting PrEP; if a candidate has acute viral infection symptoms and unprotected exposure events <1 month prior, delay PrEP for at least 1 month and retest HIV-1 status or use an Food and Drug Administration (FDA) test approved for HIV-1 diagnosis, including acute or primary HIV-1 infection - Retest for HIV-1 infection at least every 3 months while the patient receives PrEP ::: Unlabeled Uses: Treatment of hepatitis B in patients with antiviral-resistant HBV or coinfection with HIV

I.V. : Treatment of acute otitis media due to H. influenzae, M. catarrhalis, or S. pneumoniae; pharyngitis/tonsillitis due to S. pyogenes, community-acquired pneumonia due to Chlamydia pneumonia, H. influenzae, M. pneumoniae, or S. pneumoniae; pelvic inflammatory disease (PID) due to C. trachomatis, N. gonorrhoeae, or M. hominis; genital ulcer disease (in men) due to H. ducreyi (chancroid); acute bacterial exacerbations of chronic obstructive pulmonary disease (COPD) due to H. influenzae, M. catarrhalis, or S. pneumoniae; acute bacterial sinusitis due to H. influenzae, M. catarrhalis, or S. pneumoniae; prevention of Mycobacterium avium complex (MAC) (alone or in combination with rifabutin) in patients with advanced HIV infection; treatment of disseminated MAC (in combination with ethambutol) in patients with advanced HIV infection; skin and skin structure infections (uncomplicated) due to S. aureus, S. pyogenes, or S. agalactiae; urethritis and cervicitis due to C. trachomatis or N. gonorrhoeae ::: Unlabeled Uses: Treatment of babesiosis; cat scratch disease; gonococcal infections of the pharynx or rectum (combination therapy) and expedited partner therapy; granuloma inguinale (donovanosis); Mycoplasma genitalium infections; pertussis; prophylaxis of infective endocarditis in select patients who are allergic to penicillin and undergoing dental procedures; prevention of pulmonary exacerbations in patients with noncystic fibrosis bronchiectasis

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::: Unlabeled Uses: Brain abscess (postneurosurgical prevention).

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