Practice guidelines and reminders to reduce duration of hospital stay for patients with chest pain.  JH Oral ondansetron in the prevention of postoperative nausea and vomiting. Tools: File Download (358.4 KB) Final Published Version; Export Citation ; Share. John Patka, Grady Health System. The medical resident specifically started her on prochlorperazine 10 mg PO Q8H instead of ondansetron due to ongoing constipation for the last week and a half. The baseline characteristics of the ondansetron and prochlorperazine groups are listed in Patients in the ondansetron group were 3.4 times more likely to experience nausea (Multivariate analysis identified predictor variables for the occurrence of an emetic episode as obesity (odds ratio, 12.0; 95% confidence interval, 2.0-72.2; Differences in the incidence of PONV based on type of joint replacement procedure, patient sex, obesity, history of PONV, method of postoperative analgesia, and method of surgical anesthesia are shown in A greater proportion of ondansetron-treated patients (46% [17/37]) required supplemental rescue doses compared with prochlorperazine-treated patients (27% [11/41]) (odds ratio, 2.3; 95% confidence interval, 0.9-6.0; The proportion of patients who had cancelled at least 1 physical therapy session because of PONV was similar in both treatment groups (11% [4/37] vs 7% [3/41] for the ondansetron and prochlorperazine groups, respectively; The cost of drug therapy per patient (prophylactic dose plus supplemental rescue doses) associated with the ondansetron group was approximately 19 times greater than that of the prochlorperazine group.
Therefore, each patient received both an intravenous and an intramuscular injection.  TJAlexander  MMinassian Gan This site needs JavaScript to work properly. Leeser  MJPavy Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Ondansetron is a well‐established, effective, but expensive anti‐emetic drug that has been widely used in the prevention of PONV [13-15]. Read our disclaimer for details.

Daniel Wu, Emory University.  ATuominen sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto download free article PDFs, sign up for alerts, customize your interests, and moreto make a comment, download free article PDFs, sign up for alerts and more Dr Chen is now with the Department of Pharmacy, Huntington Memorial Hospital, Pasadena, Calif.Preoperative Autologous Donation Decreases Allogeneic Transfusion but Increases Exposure to All Red Blood Cell TransfusionMelissa A. Forgie, MD; Philip S. Wells, MD; Andreas Laupacis, MD; Dean Fergusson, MHA; for the International Study of Perioperative Transfusion (ISPOT) Investigators Ondansetron rated 7.9/10 vs … For the induction of anesthesia, patients received intravenous fentanyl citrate and midazolam hydrochloride. Rescue doses for nausea were administered if vomiting occurred or if requested by the patient.  MRCCampbell

 TMWheeler  MMDuncan Methods: This was a prospective, randomized, active controlled, double-blinded study.
Weingarten  RO'Connor This observation is not surprising given the greater incidence of PONV in the ondansetron group.

References Patients were allowed to receive supplemental oral or parenteral doses of analgesics at the discretion of the attending physician.During the 48-hour postoperative period, nurses assessed for and documented the presence and severity of nausea or vomiting at 14 predefined time intervals. Bodner  GEGratz  M Double-blind comparison of ondansetron, droperidol and saline in the prevention of postoperative nausea and vomiting. The results of this randomized, double-blind study demonstrates that, compared with ondansetron, prochlorperazine provides superior control of PONV in patients undergoing total hip replacement or total knee replacement procedures.The incidence of nausea and vomiting in this study is greater than that reported by others for this patient population.Of interest are the contrasting sex-specific outcomes between the ondansetron- and prochlorperazine-treated patients. There have been limited studies on the use of these agents in the ED, and no direct comparisons to 5-HT3 antagonists have been published to date.Patients presenting to the ED with at least one of the following Listing a study does not mean it has been evaluated by the U.S. Federal Government. Free PMC article

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 BWetchler Not Available, Zofran [package insert].  BWetchler  M preferences for immediate postoperative recovery [abstract]. Gan  L All Rights Reserved 1998;158(19):2124-2128. doi:10.1001/archinte.158.19.2124Limited data are available on the efficacy of ondansetron hydrochloride compared with prochlorperazine maleate for the treatment of postoperative nausea and vomiting (PONV).To evaluate the comparative efficacy of ondansetron and prochlorperazine for the prophylaxis of PONV in patients undergoing total hip replacement or total knee replacement procedures.A randomized, double-blind, comparative trial was conducted at a tertiary care, university hospital. Jellish WS, Owen K, Fluder E, Sawicki K, Sinacore J.J Clin Anesth.  K Droperidol, alizapride and metoclopramide in the prevention and treatment of post-operative emetic sequelae.  H Prevention of postoperative nausea and vomiting using ondansetron, a new, selective, 5-HTLarijani

2008 Dec;20(8):594-600. doi: 10.1016/j.jclinane.2008.06.008.Acad Emerg Med. COVID-19 is an emerging, rapidly evolving situation. Compare Ondansetron vs Promethazine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more.

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