LHRH analogs decrease the production of testosterone by your testicles and lower testosterone levels in your body. These include drugs such as leuprolide acetate (Lupron, Eligard) and goserelin acetate (Zoladex). Because of the potential for serious adverse reactions in a breastfed child, advise women not to breastfeed during treatment with Docetaxel injection and for 1 week after the last dose.Verify pregnancy status in females of reproductive potential prior to initiating Docetaxel injection.Docetaxel injection can cause fetal harm when administered to a pregnant woman [Based on genetic toxicity findings, advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 3 months after the last dose of Docetaxel injection.Based on findings in animal studies, Docetaxel Injection may impair fertility in males of reproductive potential [The efficacy of Docetaxel in pediatric patients as monotherapy or in combination has not been established. For instance, some interactions can interfere with how well a drug works. Nine of 92 patients (9.8%) of patients discontinued treatment due to fluid retention: 4 patients discontinued with severe fluid retention; the remaining 5 had mild or moderate fluid retention. These drugs can work by affecting cell survival or by boosting the immune system in its efforts to combat the abnormal cells.

6.1 Clinical Studies in High-Dose Methotrexate Therapy 6.2 Clinical Studies in Combination with 5 -FU in Colorectal Cancer Using Casodex with an LHRH analog can slow down or stop the growth of prostate cancer.Casodex comes as tablets that you take by mouth once a day. Subjective sensations of dysphagia or dyspnea, without any laryngospasm or bronchospasm (no stridor or wheezing) occurred in patients previously treated for advanced colorectal cancer.Avoid topical application of ice for mucositis prophylaxis or other conditions, because cold temperature can exacerbate acute neurological symptoms Delayed neuropathy typically presents as a persistent (greater than 14 days), primarily peripheral sensory neuropathy that is usually characterized by paresthesias, dysesthesias, and hypoesthesias, but may also include deficits in proprioception that can interfere with daily activities (e.g., writing, buttoning, swallowing, and difficulty walking from impaired proprioception).
Zytiga contains the active drug abiraterone acetate.

Delayed neuropathy can occur without any prior acute neuropathy. Patients whose disease did not progress received radiotherapy (RT) according to institutional guidelines (TPF/RT). In the Docetaxel injection weekly arm, no overall survival advantage was demonstrated compared to the mitoxantrone control arm.
Both of these drugs are hormone therapies. Oxaliplatin is a radiation-sensitizing agent. At the 28-day follow-up after the last treatment cycle, 60% of patients had any grade (grade 1=40%, grade 2=16%, grade 3=5%) peripheral sensory neuropathy, decreasing to 39% at 6 months of follow-up (grade 1=31%, grade 2=7%, grade 3=1%) and 21% at 18 months of follow-up (grade 1=17%, grade 2=3%, grade 3=1%).In the advanced colorectal cancer trials, neuropathy was graded using the neurotoxicity scale summarized in Pain or functional impairment that interfered with daily activitiesPersistent impairment that is disabling or life-threateningNeuropathy occurred in 82% (all grades) of patients previously untreated for advanced colorectal cancer, including 19% grade 3-4; and in 74% (all grades) of patients previously treated for advanced colorectal cancer, including 7% grade 3-4.PRES occurred in less than 0.1% of patients across clinical trials Oxaliplatin has been associated with pulmonary fibrosis (less than 1% of patients), which may be fatal In the adjuvant treatment trial, the combined incidence of cough and dyspnea was 7.4% (any grade), including less than 1% (grade 3) in the Oxaliplatin arm. All rights reserved.

Bicalutamide is a white to off-white powder which is practically insoluble in water at 37°C (5 mg per 1000 mL), slightly soluble in chloroform and absolute ethanol, sparingly soluble in methanol, and soluble in acetone and tetrahydrofuran. These forms of neuropathy occurred in 48% of patients receiving Oxaliplatin. The symptoms can be precipitated or exacerbated by exposure to cold temperature or cold objects and they usually present as transient paresthesia, dysesthesia and hypoesthesia in the hands, feet, perioral area, or throat. At the end of the follow-up period (actual median follow-up time of 8 years), lymphedema was observed to be ongoing in 6 TAC patients (0.8%) and 1 FAC patient (0.1%).In study TAX316, asthenia that started during the treatment period and persisted into the follow-up period after the end of chemotherapy was reported in 236 of 744 TAC patients (31.7%) and 180 of 736 FAC patients (24.5%). These reactions were described using COSTART terms and were considered possibly or probably related to Docetaxel.

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