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The uptake of propranolol was saturable and was decreased at 2.5 degrees C, suggesting an active transport mechanism.
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This was shortly followed by normal uterine activity and delivery without any significant maternal or fetal complications. HighWire Intravenous propranolol was administered to ten primigravidae with typical dysfunctional labour. Concentration-effect curves for inhibition by propranolol or tetracaine were shifted to the left by halothane. Unable to load your collection due to an error The increased uptake of propranolol in the presence of halothane was probably insufficient to account for the synergism noted. 2009 Jan 30;121(3):433-43. doi: 10.1016/j.jep.2008.10.022. Intravenous propranolol was administered to ten primigravidae with typical dysfunctional labour. The betaadrenoceptor blocking drugs: A perspective, High-pressure liquid chromatographic method for the simultaneous quantitative analysis of propranolol and 4-hydroxypropranolol in plasma, Journal of Chromatography B: Biomedical Sciences and Applications, Effect of propranolol on fetal tachycardia in diabetic pregnancy, Wave-form analysis of intrauterine pressure curves with methods and models developed in cardiac research, Effect of propranolol infusion on the umbilical and uterine circulations of pregnant sheep,
To the best of our knowledge this is the first attempt to treat dysfunctional labour by the intravenous administration of a beta‐blocking agent, and our preliminary results are encouraging.Please check your email for instructions on resetting your password. The tissue/medium ratio for propranolol was increased by halothane. By continuing to browse this site, you agree to its use of cookies as described in our BJOG: An International Journal of Obstetrics & GynaecologyAustralian and New Zealand Journal of Obstetrics and GynaecologyI have read and accept the Wiley Online Library Terms and Conditions of UsePerinatal anxiety: approach to diagnosis and management in the obstetric setting, Quantitative Spectrophotometric Determination of Propranolol Hydrochloride in Pharmaceuticals Using Cerium(IV) Sulphate as Oxidimetric Reagent, Proceedings of the National Academy of Sciences, India Section A: Physical Sciences, Effect Of β‐Receptor Blockers On Uterine Contractility In A Puerperal Model, A double blind, randomized trial on augmentation of labour with a combination of intravenous propranolol and oxytocin versus oxytocin only, European Journal of Obstetrics & Gynecology and Reproductive Biology, PROPRANOLOL FOR THE TREATMENT OF HYPERTENSION IN PREGNANCY, BJOG: An International Journal of Obstetrics & Gynaecology, The Tocolytic Effect of Catecholamines in the Gravid Rat Uterus, The Tocolytic Effect of Catecholamines in the Gravid Rat Uterus, Sequential Injection Method for the Determination of Oxprenolol in Pharmaceutical Products Using Chemometric Methods of Optimization, Comparison of two extraction methods for determination of propranolol and furosemide in human plasma by mixed-mode chromatography, Journal of Pharmaceutical and Biomedical Analysis, Kinetic Determination of Oxprenolol in Pharmaceutical Preparations, Baillière's Clinical Endocrinology and Metabolism, Kinetic determination of propranolol in tablets by oxidation with ceric sulphate, Journal of Pharmaceutical and Biomedical Analysis, Clinical pharmacology of the new betaadrenergic blocking drugs. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Halothane and other volatile anesthetics were found to relax uteri maximally contracted by oxytocin and to enhance the relaxant effect of propranolol and other agents (tetracaine, quinidine and chlorpromazine) with local anesthetic properties. Methods: A double blind randomized controlled trial was performed on 150 nulliparas with a gestational age of 39-41 weeks of pregnancy and a Bishop score of < or =5. Anderson WG, Miller JW. Labour pains associated with fear and anxiety increase the blood level of catecholamines. Mitrani A, Oettinger M, Abinader EG, Sharf M, Klein A. Labour pains associated with fear and anxiety increase the blood level of catecholamines. Name must be less than 100 characters
HighWire Propranolol administration was associated with a markedly reduced cesarean rate among patients with inadequate uterine contractility. Thaina P, Tungcharoen P, Wongnawa M, Reanmongkol W, Subhadhirasakul S.J Ethnopharmacol.
Epub 2008 Nov 5.Chulia S, Noguera MA, Fayos G, Anselmi E, Ivorra MD, D'Ocon MP.Methods Find Exp Clin Pharmacol.
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