Benzodiazepines, such as diazepam (Valium, Diastat) or lorazepam (Ativan), can help control agitation, seizures and muscle stiffness. Free PMC article Symptoms may start soon after you take a new medication or increase the dose.
2002 Apr;36(4):641-3. doi: 10.1345/aph.1A302.Cureus. Serotonin syndrome symptoms may be mild or severe.
The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. Depending on your symptoms, you may receive the following treatments: Muscle relaxants. doi: 10.2169/internalmedicine.56.7727.
Ann Pharmacother. The best diagnostic criteria, with good sensitivity (84%) and specificity (97%), are the Hunter Serotonin Toxicity Criteria (HSTC). Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and muscle rigidity were consistent with a diagnosis of serotonin syndrome (SS) according to the Hunter criteria. A 40-year-old woman with bipolar disorder who was taking mirtazapine presented with mydriasis, abnormal diaphoresis, myoclonus and muscle rigidity after taking metocloplamide.
An 8-year-old girl with behavioral problems and medicated with risperidone and sertraline was admitted in the emergency department after she had taken voluntarily 1500 mg of sertraline (50 mg/kg). Please enable it to take advantage of the complete set of features! doi: 10.7759/cureus.6359.
Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services.The serotonin syndrome is a potentially life-threatening drug reaction that may result from therapeutic medication use, self-poisoning, or interactions between drugs.
doi: 10.2169/internalmedicine.56.7727.
The steady increase in use of such drugs means all doctors need to be aware of what drugs increase serotonin and how to promptly recognise the syndrome and determine if it is potentially life threatening. Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. It manifests as a wide variety of signs reflecting the triad of CNS, autonomic and neuromuscular dysfunction. Serotonin syndrome is often not diagnosed secondary to mild symptoms that are attributed to being a general side effect of treatment, unawareness of the syndrome, varying diagnostic criteria, or misdiagnosis.
Name must be less than 100 characters Clipboard, Search History, and several other advanced features are temporarily unavailable. INTRODUCTION — Serotonin syndrome, also referred to as serotonin toxicity, is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system (CNS). Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. Concise summaries and expert physician commentary that busy clinicians need to enhance patient care.The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams.NEW!
Serotonin syndrome is a potentially life-threatening drug effect.
Her medical history, which included the use of serotonergic agents, and the presence of symptoms including myoclonus and mus … Perioperative diagnosis of serotonin syndrome can be facilitated by the use of the Hunter serotonin toxicity criteria, which are based on a specific set of clinical features in specific combinations and which have a sensitivity of 84% and a specificity of 97%. Serotonin syndrome is a potentially fatal and largely avoidable adverse drug reaction caused by serotonergic drugs. Serotonin syndrome is a drug induced syndrome … 2019 Dec 12;11(12):e6359.
Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Information, resources, and support needed to approach rotations - and life as a resident.Valuable tools for building a rewarding career in health care.Information and tools for librarians about site license offerings.The authorized source of trusted medical research and education for the Chinese-language medical community.The most trusted, influential source of new medical knowledge and clinical best practices in the world. The degree of symptoms can range from mild to severe. Case Report.
Some cases of serotonin syndrome can be life-threatening.
Are you a member of an institution such as a university or hospital?Supported in part by a grant from the National Institute on Drug Abuse (DA-14929, to Dr. Boyer).This article (10.1056/NEJMra041867) was updated on October 21, 2009, at NEJM.org.From the Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts, Worcester (E.W.B.
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