The 1,000 mg tablets have 3 score lines and can be split into 4 parts (each 250 mg). It is practically insoluble in water. The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. Dexamethasone sodium phosphate injection USP is a sterile, clear, colorless solution, free from visible particles and a water-soluble inorganic ester of dexamethasone which produces a rapid response even when injected intramuscularly.Dexamethasone Sodium Phosphate USP, C22H28FNa2O8P, has a molecular weight of 516.41 and chemically is Pregn-4-ene-3, 20-dione, 9-fluoro-11, 17-dihydroxy-16-methyl-21 (phosphonooxy)-, disodium salt, (11β, 16α).It occurs as a white to practically white powder, i… Advise males of reproductive potential to use effective contraception during and after treatment with Siklos for at least 6 months after therapy Cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, have occurred in patients with myeloproliferative disorders during therapy with hydroxyurea. Reduce dosage and closely monitor the hematologic parameters when Siklos is to be administered to these patients Close monitoring of hematologic parameters is advised in patients with hepatic impairment receiving Siklos.Acute mucocutaneous toxicity has been reported in patients receiving hydroxyurea at doses several times above the therapeutic dose. The median (range) change was 0.5 g/dL (-4.6, 6.1) in 63 patients at 6 months (the post-baseline value closest to 6 months collected between 5 and 7 months) and 0.7 g/dL (-6.4, 6.0) in 83 patients at 12 months (the post-baseline value closest to 12 months collected between 10 and 14 months) after initiation of Siklos treatment.Among pediatric patients not previously treated with hydroxyurea prior to enrollment and analyzable for efficacy (N=141), the percentage of patients with at least one vaso-occlusive episode, one episode of acute chest syndrome, one hospitalization due to SCD or one blood transfusion decreased after 12 months of Siklos treatment (Table 3).OSHA Hazardous Drugs. Advise males of reproductive potential to use effective contraception during and after treatment with SIKLOS for at least 6 months after therapy Cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, have occurred in patients with myeloproliferative disorders during therapy with hydroxyurea. Advise protection from sun exposure and monitor for the development of secondary malignancies.Based on the mechanism of action and findings in animals, Siklos can cause fetal harm when administered to a pregnant woman. If contact with crushed tablets occurs on the skin, wash affected area immediately and thoroughly with soap and water. The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. The 1,000 mg tablets have 3 score lines a nd can be split into 4 parts (each 250 mg). The molecular formula is C 22 H 29 FO 5. Males with female sexual partners of reproductive potential should use effective contraception during and after treatment with Siklos for at least 6 months after therapy Based on findings in animals and humans, male fertility may be compromised by treatment with Siklos. • Don’t stop taking this medicine without talking to your doctor – you may need to … Follow applicable special handling and disposal procedures Reduce the dose of Siklos by 50% in patients with creatinine clearance of less than 60 mL/min or with end-stage renal disease (ESRD) Monitor the hematologic parameters closely in these patients.Hydroxyurea causes severe myelosuppression. Do not use Siklos for a condition for which it was not prescribed. You and your healthcare provider should talk about Siklos when you start taking it and at regular checkups.Siklos 100 mg tablet Siklos 1,000 mg tablet (broken)The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
It is designated chemically as 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene,3,20-dione and the structural formula is: CLINICAL … Mean peak plasma concentrations and AUCs increase more than proportionally with increase of dose.There are no data on the effect of food on the absorption of hydroxyurea.Hydroxyurea distributes throughout the body with a volume of distribution approximating total body water.
If contact with crushed tablets occurs on the skin, wash affected area immediately and thoroughly with soap and water. SIKLOS 1,000 mg Tablet Breaking Instructions: You will need the following supplies to break a SIKLOS 1,000 mg tablet: SIKLOS … Use of Siklos in these age groups is supported by evidence from a non-interventional cohort study, the European Sickle Cell Disease prospective Cohort study, ESCORT-HU, in which 405 pediatric patients ages 2 to <18 were enrolled. However, hydroxyurea is presumed to be a transspecies carcinogen. The most frequent serious adverse reactions were infections (17.8 %), and blood and lymphatic system disorders (9.1 %).
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