Theophylline should be stored away from moisture, heat and light and should be kept at room temperature. The dose rate of theophylline varies depending on the preparation used. The increased g-globulins are IgA and IgG while IgM levels remain unchanged.
These include increasing intracellular concentrations of inositol 1,4,5-triphosphate (ITP) and diacylglycerol (DAG) as well as promoting Ca influx through L-type Ca channels. In this situation mucolytic therapy may have some value in facilitating resolution of the inflammatory airway disease. When using the sustained release preparations a dose of 20mg/kg/12h for dogs and 25mg/kg/24h for cats should be considered. During treatment the dog will need to be carefully monitored, both for the r… -Because of differences in theophylline clearance, the dose needed to achieve a peak theophylline of 10 to 20 mcg/mL varies up to fourfold (e.g. These drugs have a number of pharmacologic effects including relaxation of bronchial smooth muscle, bronchial anti-inflammatory actions, central nervous system stimulation, mild diuresis, increased gastric acid secretion and mild cardiac stimulation. In some cases, blood levels of the medication may be monitored to be sure the dose is correct.Theophylline tablets or oral liquid should be stored at room temperature, below 30°C (86°F), in a tightly closed container.If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. Afferent conduction from these receptors is via the vagus too possibly multiple centres within the medulla that are distinct from the actual respiratory centre. Included in the drug classification as smooth muscle relaxant, the medication is active against conditions affecting the respiratory muscles of dogs and cats. Wellness Advice The antitussive dose of butorphanol in dogs is 0.55-1.1mg/kg/6-12h orally or 0.055-0.11mg/kg/6-12h subcutaneously. Therapeutic plasma concentrations, extrapolated from people, are 5–20 mcg/mL. Note: Do not give your dog theophylline unless it has been recommended by your vet, and always follow the vet’s exact dosing recommendations.
While mucoprotein is the main determinant of viscosity in normal mucus, in purulent inflammation the mucoid concentration of DNA increases (due to increased cellular debris) and so does its contribution to mucoid viscosity.
The drugs that can affect this complex mechanism are quite diverse. When using the sustained release preparations a dose of 20mg/kg/12h for dogs and 25mg/kg/24h for cats should be considered. Pets with liver disease or heart failure should receive lower doses of the medication. However, evidence for its efficacy in this role is lacking in animals and currently its use in veterinary practice is confined to its significant muscle relaxant activity. Although this first phase may be AMP-independent, both ITP and DAG levels appear to be involved in the maintenance of contraction via modification of cAMP levels through unknown mechanisms.
Whatever the starting point, the dose may need to be increased to achieve a satisfactory effect.
The cells of the respiratory tract produce mucus that traps dirt and this mucus is moved to the throat by the beating action of the cilia.Theophylline should be administered 2 to 3 times a day and the suggested dosage for dogs is 2.25 to 5 grams of medication per pound of weight of the pet. Respiratory diseases in dogs and cats can be classified into respiratory problems brought about as a result of a specific abnormality of the respiratory system; so called primary respiratory disease, and bronchopulmonary problems which occur as a consequence of heart failure; so called secondary respiratory disease. Theophylline reduces the effectiveness of beta blockers. However sustained release preparations may have a more variable bioavailability. Shop By Pet Both are vaporised in the spacer, the face mask placed over the cat's face and it is allowed to breath through the mask for 7-10 seconds.
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