Reference Ranges: Normal: 68 – 150 mU/L Low: 20 – 67 mU/L With this result, there is a 100% chance of developing toxicity within the bone marrow should a thiopurine drug be administered.Rare variants are not necessarily detected by this test. People who have had a recent blood transfusion also tend to test artificially low for enzyme activity. Das Enzym kommt im Zytosol von Tieren, Pflanzen und Bakterien vor. Unable to load your collection due to an error 2004 Jul;41(Pt 4):294-302. doi: 10.1258/0004563041201455.Morishita M, Watanabe H, Yan M, Zeggar S, Hiramatsu S, Ohashi K, Miyawaki Y, Katsuyama E, Katsuyama T, Takano Narazaki M, Toyota Tatebe N, Sunahori Watanabe K, Kawabata T, Sada KE, Wada J.Intern Med. The overall goal is to track certain blood cells to measure the effectiveness of a treatment. There are no counter-indications of a TPMT blood test being above average, although it is believed that having high levels of enzyme activity could prevent a thiopurine drug being as effective as it could be.When there are two genes with variations, a standard dose of a thiopurine drug is typically used as enzyme activities will be normal. Please enable it to take advantage of the complete set of features! Clinical and Experimental Rheumatology 2017;56(13):1645-1650. doi: 10.2169/internalmedicine.56.8287.
It is also commonly used for organ transplant recipients and when a diagnosis of Crohn’s disease has been confirmed. There are two primary reasons for having this test ordered.Thiopurine drugs are used most often for autoimmune disorders, such as rheumatoid arthritis. 2007 Apr;32(2):187-95. doi: 10.1111/j.1365-2710.2007.00805.x.Lupus. A doctor may ordered a phenotype blood test or a genotype blood test to receive the needed TPMT results. Ca. CONCLUSIONS: This is the first study to evaluate TPMT activity in a Turkish adult population. This blood test is ordered to determine if there are variations within the TPMT gene that could contribute to low levels of enzyme activity. Das kodierende Gen TPMT liegt auf Chromosom 6. 2013 Dec;22(14):1526-8. doi: 10.1177/0961203313504636.
It is not used for tracking purposes, but is instead used in conjunction with complete blood count results.The results of the TPMT blood test will help to determine what method of treatment is best for an individual’s current health. Sometimes the test is ordered to measure the genetic structures that are in place supporting the TPMT activity instead. Chen D, Lian F, Yuan S, Wang Y, Zhan Z, Ye Y, Qiu Q, Xu H, Liang L, Yang X.Clin Rheumatol. Unable to load your delegates due to an error TPMT levels were significantly lower in those 8 patients (14.08±9.49 vs. 25.62±12.68) (p=0.013), besides a cut-off value for predicting adverse effects was determined for the BD group with ROC analysis (area under the curve: 0.813). Epub 2017 Jul 1.
90% der Bevölkerung sind homozygote Träger des Gens TPMT*1 und haben eine normale Thiopurin-Methyltransferase-Aktivität. About one person in every 300 is severely deficient in TPMT, and about 10% of the population in the U.S. has lower than normal levels of TPMT. The phenotype blood test is much more commonly ordered than the genotype blood test. This site needs JavaScript to work properly. Each test has results that mean specific things.When the results are close to normal, but are still classified as low, then there is still a risk of havingg toxicity occur due to the drug treatment. Clipboard, Search History, and several other advanced features are temporarily unavailable. People who are receiving thiopurine drugs and have a low white blood cell count may have the TPMT blood test ordered a second time to confirm first-time results. Your doctor will likely request that you abstain from NSAID pain relievers, certain diuretics, and benzoic acid inhibitors for at least 48 hours before the TPMT blood test. Name must be less than 100 characters As such, knowing a patient’s TPMT status prior to treatment with azathioprine or 6-MP is important for purposes of calculating drug dosages. Epub 2013 Sep 12.Ann Clin Biochem.
Instead of measuring the actual activity levels, the test looks to see if there are one of two known “rogue” copies of the TPMT gene or if one of the TPMT genes is associated with a negative gene variation.
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