Sanctura; Descriptions. The QT interval was measured over a 24-hour period at steady state. Therefore, anticholinergic adverse reactions (including dry mouth, constipation, dyspepsia, urinary tract infection, and urinary retention) are expected to be greater in patients with moderate renal impairment [Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.The safety of Trospium Chloride was evaluated in controlled clinical trials in a total of 2975 patients, who were treated with Trospium Chloride (N=1673), placebo (N=1056) or active control medications (N=246). This leaflet does not take the place of talking with your doctor about your medical condition or your treatment.Trospium Chloride tablets are a prescription medicine used to treat adults with overactive bladder who have the following symptoms:Trospium Chloride tablets has not been studied in children under the age of 18 years.Tell your doctor about all of your medical conditions including if you:Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements.
Patients should be informed that alcohol may enhance the drowsiness caused by anticholinergic agents.Read the Patient Information that comes with Trospium Chloride tablets before you start taking it and each time you get a refill.
The overall symptom score, urgency, urge incontinence, flank pain, urethral pain and gross hematuria scores were significantly lower in solifenacin group compared to trospium chloride and placebo groups (p < 0.001). This means it is still under development and may contain inaccuracies. If you experience these symptoms, you should stop taking Trospium Chloride tablets and get emergency medical help right away.The most common side effects with Trospium Chloride tablets are:Trospium Chloride tablets may cause other less common side effects, including:Tell your doctor if you have any side effects that bother you or that do not go away.These are not all possible side effects of Trospium Chloride.
Following admission into the hospital and about 1 hour after ingestion of the trospium, medicinal charcoal was administered for detoxification. A maternal no-effect level was set at 20 mg/kg/day, at an exposure approximately equivalent to the maximal recommended human dose (MRHD) of 40 mg, due to clinical signs (reduced feces, hunched posture, diarrhea) observed in a pharmacokinetic study at 200 mg/kg/day.The effect of Trospium Chloride tablets on labor and delivery is unknown.Trospium Chloride (2 mg/kg orally and 50 mcg/kg intravenously) was excreted, to a limited extent (less than 1%), into the milk of lactating rats (primarily as parent compound). However, maternal toxicity (death, irregular breathing, increased excitability) was observed at 200 mg/kg/day. Each Trospium Chloride tablet also contains the following inactive ingredients: black iron oxide, confectioners' sugar, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, shellac, silicon dioxide, talc and titanium dioxide.Trospium Chloride antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. This finding was not observed during routine safety monitoring in 2 other placebo-controlled clinical trials in 591 Trospium Chloride treated overactive bladder patients [A summary of mean (± standard deviation) pharmacokinetic parameters for a single 20 mg dose of Trospium Chloride tablets is provided in Table 2.The mean plasma concentration-time (+ SD) profile for Trospium Chloride is shown in Figure 1.The apparent volume of distribution for a 20 mg oral dose is 395 (± 140) liters.The mean renal clearance for trospium (29.07 L/hour) is 4-fold higher than average glomerular filtration rate, indicating that active tubular secretion is a major route of elimination for trospium.
You can ask your doctor or pharmacist for information about Trospium Chloride tablets that is written for health professionals.
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