If you come in contact with an allergen, histamine helps your body get rid of it. Our bodies need histamine. But sometimes our bodies produce too much histamine in response to a harmless allergen, like pollen, leaving you with a runny nose and itchy eyes. Some older antihistamines, like Periactin (cyproheptadine), were actually given to people for the purpose of increasing their appetite and weight gain. Moreover, the target group to which Periactin was given was cancer patients and underweight children. Antihistamines are oral medications that are commonly used to treat symptoms of allergic rhinitis and allergic conjunctivitis. Drugs that cause the most weight gain tend to raise your blood’s sugar and fat levels.

Antihistamines that can cause weight gain include: Diphenhydramine (Benadryl and others) Cetirizine (Zyrtec) Levocetirizine (Xyzal) Fexofenadine (Allegra) Hydroxyzine (Atarax, Vistaril) Chlorpheniramine maleate (Chlor-Trimeton) If you need to take an antihistamine your best bet is loratadine (Claritin). By using Verywell Health, you accept our Antihistamines are known to cause weight gain. That's where antihistamines can help. Another theory why antihistamines cause weight gain is that they increase appetite. My thyroid levels are in normal range. In fact, one antihistamine, cyproheptadine, has been used for this purpose. Decreased levels of energy caused by antihistamines intake in turn cause the lack of desire for performing physical activity that prevents physical activities such as running, jogging, This article on Epainassist.com has been reviewed by a medical professional, as well as checked for facts, to assure the readers the best possible accuracy.We follow a strict editorial policy and we have a zero-tolerance policy regarding any level of plagiarism. Antihistamines are particularly useful for treating common allergy symptoms such as Some older antihistamines, such as Benadryl, cause some well-known side effects such as dry mouth, drowsiness, and urination problems. Ⓒ 2020 About, Inc. (Dotdash) — All rights reservedDaniel More, MD, is a board-certified allergist and clinical immunologist. But sometimes our bodies produce too much histamine in response to a harmless allergen, like pollen, leaving you with a runny nose and itchy eyes. Nothing seems to help. What to do: Talk to your doctor about going on an antidepressant that’s known to cause the least amount of weight gain.

This article may contains scientific references. It has long been known that the administration of antihistamines can cause weight gain. Having a Type 1 Latex Allergy which is very severe I am on high maintenance doses of Allegra, Claritin, Zyrtec every day. On the other side, newer Obesity journal has published a study in 2010 that featured an association between the usage of antihistamines and Some scientists theorize that antihistamines promote obesity since their structure is similar to the structure of psychiatric drugs that are associated with weight gain.

Verywell Health uses cookies to provide you with a great user experience. He is an assistant clinical professor at the University of California, San Francisco School of Medicine and currently practices at Central Coast Allergy and Asthma in Salinas, California.Do You Take an Antihistamine for Your Nasal Allergies?Benefits and Side Effects of Treating Hives or Allergies With ZyrtecUsing Over-the-Counter Medication for Your Allergy Symptoms Read our Antipsychotics with a lower risk of weight gain are: Aripiprazole ( Abilify ) Alternatively, obesity is considered to be an inflammatory condition that makes a person more prone to problems such as allergies. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.The feedback link “Was this Article Helpful” on this page can be used to report content that is not accurate, up-to-date or questionable in any manner. If antihistamines make you drowsy, your decreased energy levels could result in less exercise and more weight gain. Therefore antihistamines use is simply a marker for allergies, not the cause of the weight gain. Older antihistamines, such as Periactin (cyproheptadine), have actually been used for the purpose of increasing appetite and weight gain in underweight children and cancer patients undergoing chemotherapy. Antihistamines may also increase appetite, which can cause weight gain. There are many postulations as to why this occurs. Our articles are resourced from reputable online pages. In a NHANES survey conducted in 2005 to 2006, antihistamine use was associated with excess weight, while a study from Yale University researchers confirmed this association and analyzed the use of over-the-counter antihistamines and their effect on weight gain. It is very possible that the intake of antihistamines may cause Antihistamines can be defined as commonly used over-the-counter medications that treat the symptoms of allergic conjunctivitis and allergic rhinitis. If you come in contact with an allergen, histamine helps your body get rid of it. The reasons for this weren't clear, and it's important to note that this association doesn't mean that antihistamines directly cause weight gain.

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