Theophylline Derivatives may decrease the serum concentration of CarBAMazepine. Theophylline increases the force of contraction of diaphragmatic muscles through enhancement of calcium uptake through adenosine-mediated channels.Theophylline: ~0.45 L/kg based on ideal body weight; distributes poorly into body fat; VTheophylline: Hepatic via demethylation (CYP 1A2) and hydroxylation (CYP 2E1 and 3A4); forms active metabolites (caffeine and 3-methylxanthine).Theophylline: Urine (~50% as unchanged drug [Neonates]; ~10% as unchanged drug [Infants >3 months, Adolescents, and Adults])Theophylline: Highly variable and dependent upon age, hepatic function, cardiac function, lung disease, and smoking historyPremature infants, postnatal age 3 to 15 days: 30 hours (range: 17 to 43 hours)Premature infants, postnatal age 25 to 57 days: 20 hours (range: 9.4 to 30.6 hours)Term infants, postnatal age 1 to 2 days: 25.7 hours (range: 25 to 26.5 hours)Term infants, postnatal age 3 to 30 weeks: 11 hours (range: 6 to 29 hours)Children 1 to 4 years: 3.4 hours (range: 1.2 to 5.6 hours)Children and Adolescents 6 to 17 years: 3.7 hours (range: 1.5 to 5.9 hours)Adults ≥18 years to ≤60 years (asthma, nonsmoking, otherwise healthy): 8.7 hours (range: 6.1 to 12.8 hours)Elderly >60 years (nonsmoking, healthy): 9.8 hours (range: 1.6 to 18 hours)Theophylline: ~40%, primarily to albumin; decreased in neonates (due to a greater percentage of fetal albumin), hepatic cirrhosis, acidemia (uncorrected), elderly, third trimester of pregnancy.Clearance is decreased in infants <3 months with decreased renal function.Clearance is decreased by ≥50% in patients with hepatic impairment (eg, cirrhosis, acute hepatitis, cholestasis).Clearance is decreased by an average of 30% in patients >60 years.Clearance is very low in neonates and reaches max values by 1 year of age, remains relatively constant until about 9 years of age, and then slowly decreases by approximately 50% to adult values at about 16 years of age. Note: All dosages expressed as aminophylline; use ideal body weight (theophylline distributes poorly into body fat) to calculate dose; individualize dose based on steady-state serum concentrations. The treatment of asthma exacerbations with aminophylline is not supported or recommended by current clinical … Kamagra Gold - a reduced remedy that betters an additional function. Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Zafirlukast may increase the serum concentration of Theophylline Derivatives. Measurement of plasma-theophylline concentration may be helpful and is essential if a loading dose of intravenous aminophylline is to be given to patients who are already taking theophylline, because serious side-effects such as convulsions and arrhythmias can occasionally precede other symptoms of toxicity. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iopamidol. Management: Seek alternatives when possible. Aminophylline relaxes smooth muscle and relieves bronchial spasm. Theophylline may decrease triiodothyronine.Frequency not defined. The use of Aminophylline IV in children under 6 months of age is not recommended. Theophylline toxicity is most likely to occur when serum concentrations exceed 20 micrograms/ml and becomes progressively more severe at higher serum concentrations.Fatalities in adults have occurred during IV Aminophylline administration in large doses in patients with renal, hepatic or cardiovascular complications or where the injection has been given rapidly.
Theophylline Derivatives may enhance the hypokalemic effect of Indacaterol. Iohexol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iohexol. Because of the risk of uncontrolled asthma, their safety during pregnancy when clearly needed is generally not seriously questioned.
Management: Avoid using aminophylline or other methylxanthines (eg, caffeine) for at least 12 hours prior the the administration of regadenoson.Riociguat: Theophylline Derivatives may enhance the hypotensive effect of Riociguat. Management: Reduce initial doses of sympathomimetic agents, and closely monitor for enhanced pressor response, in patients receiving linezolid.
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