The mean terminal elimination half-life was approximately 8 hours.

Blood pressure was lower starting at week 4 in the 1 mg/kg group, at week 2 in the 3 mg/kg group, and during the first week in the 5 mg/kg group.
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Approximately 30% of cats in both groups were fed a commercial kidney diet when being allocated to the study.Primary and secondary efficacy analysis was based on the per-protocol-population (PPS) data set, including 176 valid cases (n=85 telmisartan, n=91 benazepril). Tetanus in Pets (Lock Jaw) The Wrath of Grapes.

On kidney histology, there was minimal to mild hypertrophy of the juxtaglomerular apparatus in the 1, 3, and 5 mg/kg group cats. One hundred fourteen (59.4%) SEMINTRA group cats and 42 (43.8%) control group cats had at least one adverse reaction. { deal: false, strike: false, greenbar: false } The initial dose of Semintra is 1.5 mg/kg (0.68 mg/lb) orally twice daily for 14 days, followed by 2 mg/kg (0.91 mg/lb) orally once daily.
Rinse the dosing syringe with water and let air dry. Semintra is available as a solution to be given by mouth and can only be obtained with a veterinary prescription. 0000002885 00000 n Thank you for your feedback. Inhibitor/BlockerI saved money and signed up for auto refill of my cats medicine. 0000018742 00000 n If you have vomiting or diarrhea , you may need to use a back-up birth control method (such as condoms , spermicide ). Swimmer's Ear in Dogs. Each mL contains 4 mg telmisartan, Ph. 0000003508 00000 n Cats with SBP >180 mmHg at Days 14 or 28 were rescued and removed from the study. Adverse reactions that occurred in at least 5% of either treatment group are presented in Table 1 below.Table 1 Adverse Reactions in the 28-Day Field Study Additional adverse reactions that occurred in <5% of the SEMINTRA group included (in order of decreasing frequency): anorexia, gagging, arrhythmia, cough, heart murmur, and regenerative anemia. Wash hands after use.People with hypersensitivity to telmisartan or other angiotensin II receptor antagonists should avoid contact with SemintraPregnant women should take special care to avoid accidental oral exposure because substances acting on the RAAS, such as Angiotensin Receptor Blockers (ARBs) and ACE inhibitors (ACEi) have been found to affect the unborn child during pregnancy in humans.The following transient gastrointestinal signs have rarely been observed in a field efficacy trial (in order of decreasing frequency): mild and intermittent regurgitation, vomiting, diarrhea or soft feces.Elevated liver enzymes have been very rarely observed and values normalized following cessation of therapy.Effects attributable to the pharmacological activity of the product observed at the recommended treatment dose included reductions in blood pressure and slight decreases in red blood cell counts. Adverse reactions that occurred in at least 5% of cats are presented in Table 2 below.Adverse reactions representing <5% of the study population were (in order of decreasing frequency): elevated liver enzymes, renal failure, tachycardia, arrhythmia, azotemia, depression, loose stool, constipation, gagging, hypotension, regenerative anemia, renal insufficiency, and vocalization.Nine cats died or were euthanized during the study. 4 0 obj <> endobj xref 4 47 0000000016 00000 n By Your issue has been submitted. Swimmer’s Tail in Dogs. Tetanus in Pets (Lock Jaw) The Wrath of Grapes. 0000034825 00000 n Symptoms of Cushing's Syndrome. 0000001445 00000 n Meanwhile two more had died, and the owners called me out to euthanize the sole remaining puppy that was in a coma. In case of such contact, rinse eyes with water. Steroid Use in Dogs and Cats. Cats should be monitored for weight loss when initiating treatment with SEMINTRA. Cats were evaluated for SBP, target organ damage (TOD; primarily assessed by retinal photographs), clinical pathology and adverse reactions. The safe use of Semintra has not been evaluated in cats that are pregnant, lactating, or intended for breeding.

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