The results confirmed that age was an independent risk factor for ED, and UA was an independent protective factor (Table Moreover, according to the univariate logistic regression results in Table ED is a global problem that influences a great proportion of males.
In accordance with the Declaration of Helsinki, the research was carried out.A standard procedure was executed by the same trained staff group to complete questionnaire. The theory is that high uric acid ultimately restricts the flow of blood to the penis. Data were collected in three general communities respectively. Gagliardi, A. C., Miname, M. H. & Santos, R. D. Uric Acid: A Marker of Increased Cardiovascular Risk.
Finally, a total of 1365 men were enrolled in the study. You can also search for this author in Some of the best guesses put forward by researchers include:While the actual reason for the connection between gout and erectile dysfunction isn’t completely clear, there have been a number of studies showing that these two disorders are indeed linked.Research on the correlation between these two disorders is certainly in its early stages. All authors reviewed the manuscript.The authors declare that they have no competing interests. If you wish to read unlimited content, please log in or register below. reported that hyperuricemia could be regarded as an independent risk factor for ED in addition to the established ones [ 31 ]. Fabbrini, E., Serafini, M., Colic, B. I., Hazen, S. L. & Klein, S. Effect of Plasma Uric Acid On Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. All these are known to be major causes of ED, and so if they are linked to uric acid, then uric acid must also have a role to play in causing erectile dysfunction. However, it does appear that there is a link. Although International Index of Erectile Dysfunction-5 (IIEF-5) is widely recognized for assessment of ED in both clinical and epidemiologic studies, dividing sharply whether suffering from ED or not according to the IIEF-5 score below 22 is not appropriate. Univariate logistic regression analysis showed that age [Odds ratio (OR), 95% confidence intervals (CI)] (1.057,1.046–1.069); FSH(1.054,1.031–1.077); LH (1.076,1.037–1.117); SHBG (1.012,1.007–1.017); HbA1c (1.265,1.125–1.421); FPG (1.125,1.040–1.217); systolic pressure (1.013,1.007–1.017) were significantly associated with increased odds of ED, on the contrary, both FAI (0.974,0.965–0.983) and UA (0.998,0.997–1.000) had protective effect on erectile function (Table Based on the multivariate logistic regression analysis, the adjusted OR of age to ED was 1.048 (1.030–1.067), and the OR of UA to ED was 0.998 (0.996–1.000). Indapamide (Lozol ®) may cause impotence, as is common with many blood pressure medications.In clinical studies, between 1 and 5 percent of men taking indapamide reported problems with impotence, although the exact percentage was not reported. You can also search for this author in
The conventional P < 0.05 was used to assess statistical significance.Valiquette, L. A Historical Review of Erectile Dysfunction. WASHINGTON, D.C.—Elevated serum uric acid levels may be a marker for an increased risk of erectile dysfunction (ED), Iranian researchers reported at … Hence, the possibility exists that parts of the participants didn’t fill in the IIEF-5 questionnaire honestly, and the uncontrolled factor may cause bias.In conclusion, based on this population-based cross-sectional study, we estimated the prevalence of ED in Chinese males. Seidman, S. N. & Roose, S. P. The Relationship Between Depression and Erectile Dysfunction. You can also search for this author in The relationship with erectile dysfunction comes from the fact that uric acid is strongly linked with endothelial dysfunction, hypertension and microvascular disease. Guidelines also recommend uric acid-lowering treatment if a person with gout also has kidney disease. The connections between diseases are still being understood, however, it seems clear that gout and erectile dysfunction are intertwined. The five‐item International Index of Erectile Function was used to evaluate the presence and the severity of ED.The mean serum UA levels in ED‐positive and ED‐negative groups were 6.12 ± 1.55 mg/dL and 4.97 ± 1.09 mg/dL, respectively (Our findings reveal that serum UA can be considered a risk predictor for ED.
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