Seizures have also been reported.The most frequently observed laboratory alterations which could be possibly attributable to drug administration were decreased hematocrit, transient elevation of transaminases, leukopenia and thrombocytopenia.
It is not known if Mefloquine was responsible for those suicides.If you have any of these serious mental problems, or you develop other serious side effects or mental problems, you should contact your doctor right away as it may be necessary to stop taking Mefloquine and use a different medicine to prevent malaria.Mefloquine is a prescription medicine used to prevent and treat malaria.
It is not known how well Mefloquine works to prevent malaria in children weighing less than 44 pounds (20 kilograms).Talk to your doctor before you take Mefloquine if you have any of the medical conditions listed above.Avoid activities such as driving a car or using heavy machinery or other activities needing alertness and careful movements (fine motor coordination) until you know how Mefloquine affects you.
Therefore, Mefloquine hydrochloride tablets should be used with caution when administered concomitantly with CYP3A4 inhibitors.
Available for Android and iOS devices. At doses of 5 mg/kg/day, only corneal lesions were observed. Thereafter, plasma levels of the main metabolite and Mefloquine declined at a similar rate. The clinical relevance of these interactions is not known to date.No other drug interactions are known.
If you would like more information, talk with your doctor. These are not all the possible side effects of Mefloquine.
Flashcards enregistrés Mefloquine should not be prescribed for prophylaxis in patients with active depression, generalized anxiety disorder, psychosis, or schizophrenia or other major psychiatric disorders. If a second dose is not tolerated, the patient should be monitored closely and alternative malaria treatment considered if improvement is not observed within a reasonable period of time (see Clinical studies of Mefloquine did not include sufficient numbers of subjects aged 65 and older to determine whether they respond differently from younger subjects. These alterations were observed in patients with acute malaria who received treatment doses of the drug and were attributed to the disease itself.During prophylactic administration of Mefloquine to indigenous populations in malaria-endemic areas, the following alterations in laboratory values were observed: transient elevation of transaminases, leukocytosis or thrombocytopenia.Because of the long half-life of Mefloquine, adverse reactions to Mefloquine may occur or persist up to several weeks after discontinuation of the drug.Postmarketing surveillance indicates that the same kind of adverse reactions are reported during prophylaxis, as well as acute treatment. Several of these assays were performed with and without prior metabolic activation. Splitting the total therapeutic dose into 2 doses taken 6 to 8 hours apart may reduce the occurrence or severity of adverse effects. Since electrocardiographic abnormalities have been observed in individuals treated with Mefloquine (see At the doses used for treatment of acute malaria infections, the symptoms possibly attributable to drug administration cannot be distinguished from those symptoms usually attributable to the disease itself.Among subjects who received Mefloquine for prophylaxis of malaria, the most frequently observed adverse experience was vomiting (3%).
For example, resistance of Cases of agranulocytosis and aplastic anemia have been reported (see Periodic evaluation of hepatic function should be performed during prolonged prophylaxis.Medication Guide: As required by law, a Mefloquine Medication Guide is supplied to patients when Mefloquine is dispensed.
Mefloquine does not work for all types of malaria. These are not all the possible side effects of Mefloquine.
There is evidence that Mefloquine is excreted mainly in the bile and feces.
During prophylactic use, if psychiatric or neurologic symptoms occur, the drug should be discontinued and an alternative medication should be substituted (seeIn case of life-threatening, serious or overwhelming malaria infections due to, patients should be treated with an intravenous antimalarial drug.
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