Animal data reveal no teratogenic effects, however, there are no adequate and well-controlled studies in pregnant women. 80 mg/kg/day PO in divided doses given every 8 hours (Max: 1500 mg/day) for a total of 60 days of therapy when first-line agents (fluoroquinolones, doxycycline) are not considered safe for the full treatment course.

80 to 90 mg/kg/day PO in divided doses every 12 hours (Max: 2 g/dose) is recommended for children in areas with high rates of S. pneumoniae resistance (more than 10%, including intermediate- and high-level resistance). 45 mg/kg/day PO in divided doses every 12 hours is the standard dose for children with uncomplicated disease that is mild to moderate in severity who do not attend daycare and who have not been treated with an antimicrobial agent in the previous 4 weeks. A prospective, open label study evaluated the effectiveness of levofloxacin-based dual (levofloxacin/rabeprazole) and triple (levofloxacin/amoxicillin/rabeprazole) therapy in eradicating H. pylori. 1 g PO as a loading dose followed by 500 mg PO three times daily for 3 days. Do not exceed 500 mg/dose if given every 8 hours or 875 mg/dose if given every 12 hours. While amoxicillin should be used with caution in pregnancy, penicillins are usually considered safe during pregnancy when clearly needed.

However doctors club the drug with other medicines to enhance its effect. 1750 mg/day PO for most labeled indications; up to 3000 mg/day PO is recommended off-label for community-acquired pneumonia.1750 mg/day PO for most labeled indications; up to 3000 mg/day PO is recommended off-label for community-acquired pneumonia.1750 mg/day PO for most indications; however, doses up to 4 g/day PO have been used off-label for community-acquired pneumonia.45 mg/kg/day PO for most indications; however, doses up to 90 mg/kg/day have been used off-label for acute otitis media (Max: 1750 mg/day) and community-acquired pneumonia (Max: 4 g/day).> 3 months: 45 mg/kg/day PO for most indications; however, doses up to 90 mg/kg/day have been used off-label for acute otitis media and community-acquired pneumonia.No dosage adjustment needed; amoxicillin is not appreciably metabolized in the liver and does not undergo biliary secretion.The following dosing recommendations pertain to adults. Amoxicillin is excreted in breast milk in small amounts. For less resistant pneumococcal strains (MIC of 0.5 mcg/mL), dividing 90 mg/kg/day into 2 doses will likely achieve a clinical and microbiological cure in more than 99% of children. The FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours or 25 mg/kg/day PO in divided doses every 12 hours for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours or 45 mg/kg/day PO in divided doses every 12 hours for severe infections. Unless the infant is allergic to penicillins, breast-feeding is generally safe during maternal penicillin therapy. Animal data reveal no teratogenic effects, however, there are no adequate and well-controlled studies in pregnant women. While amoxicillin may be used to treat certain sexually transmitted diseases (STD), the drug may mask or delay the symptoms of incubating syphilis when given as part of an STD treatment regimen. In general, amoxicillin should be used cautiously in patients with cephalosporin hypersensitivity or carbapenem hypersensitivity. The 400mg suspension has been studied only when administered at the start of a light meal.A false-positive reaction for glucose in the urine has been observed in patients receiving penicillins, such as amoxicillin, and using Benedict's solution, Fehling's solution, or Clinitest tablets for urine glucose testing. Do not take the drug if you are allergic to it. Cutaneous anthrax is typically treated for 7—10 days; however, when associated with a bioterrorism attack, treatment should continue for 60 days. The American Academy of Pediatrics considers amoxicillin a medication that is usually compatible with breast-feeding.

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