This site needs JavaScript to work properly. This phase I trial studies the best dose and side effects of venetoclax when given together with busulfan, fludarabine, and azacitidine in treating patients with high risk acute myeloid leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia, or myelodysplastic syndrome / myeloproliferative neoplasm undergoing donor hematopoietic stem cell transplantation. This phase II trial studies how the transplantation of laboratory expanded cord blood, called spanlecortemlocel, works in treating patients with high-risk blood cancers. This is a clinical trial that will compare survival and sickle related outcomes in adolescents and young adults with severe sickle cell disease after bone marrow transplantation and standard of care. Clipboard, Search History, and several other advanced features are temporarily unavailable. Amongst 22 patients who received a single UM171 CB transplant with a median follow-up of 18 months, risk of TRM (5%) and grade 3-4 acute GVHD (10%) were low. The purpose of the conditioning therapy is to destroy the patient's abnormal bone marrow which doesn't work properly in order to make way for the new healthy donor cells which functions normally. The donated cells may also replace the patient's immune cells and help destroy any remaining cancer cells. Please enable it to take advantage of the complete set of features! One of the side effects of a donor stem cell transplant is the development of GVHD, which occurs when some of the cells from the donor attack the recipient’s tissues, resulting in mild, moderate, or even life-threatening side effects to the recipient’s skin, stomach, intestine, and liver. 2007;8(4):189-94. doi: 10.2165/00128071-200708040-00001.Acta Dermatovenerol Alp Pannonica Adriat. This phase II trial investigates four strategies and how well they work for the reduction of graft versus host disease in patients with acute leukemia in remission. Giving tacrolimus and mycophenolate mofetil may stop this from happening. This phase I / II trial studies the side effects and best dose of bendamustine when given with or without cyclophosphamide in preventing graft versus host disease (GVHD) in patients undergoing stem cell transplant. When the healthy lymphocytes and stem cells from a donor are infused into the patient, they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. Epub 2019 Dec 30.Blood. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. In 2005, the Pediatric Advisory Committee of the US FDA implemented a 'black box' warning for tacrolimus ointment and pimecrolimus cream due to the lack of long-term safety data and the potential risk of the development of malignancies. Umbilical cord blood transplantation has been primarily used in patients with blood cancers. Donor stem cell transplants contain kinds of white blood cells called T-cells and B-cells along with all the blood-forming cells that make up a healthy immune system.
The majority of the skin tumours occurred at the site of the drug application. Using spanlecortemlocel may speed up blood count recovery in patients with high-risk blood cancers. This phase II trial studies how well a 2-step approach to stem cell transplant works in treating patients with blood cancers. 2019 Mar 14;133(11):1191-1200. doi: 10.1182/blood-2018-04-785899. When the healthy cells from a donor are infused into the participant, they may help the patient's bone marrow make stem cells, red blood cells, and platelets. Drugs used in chemotherapy, such as bendamustine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving total bone marrow and lymphoid irradiation before donor transplant and cyclophosphamide after transplant may work better at treating acute myeloid leukemia. Removing a particular type of T cell (naive T cells) from the donor cells before the transplant may stop this from happening. Giving chemotherapy and total body irradiation before or after a stem cell transplant helps kills cancer cells that are in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. Epub 2019 Jan 23.mBio. UM171 expanded CB was associated with a median neutrophil recovery at day (D)+18 post transplant.
This phase I trial studies the side effects and best dose of T cells (EAGD T-cells) after stem cell transplantation and post-transplant cyclophosphamide for the treatment of patients with blood cancer. 2017 Oct 24;8(5):e01752-17. COVID-19 is an emerging, rapidly evolving situation.
This phase I / II trial studies the best dose of sorafenib when given together with busulfan and fludarabine in treating patients with acute myeloid leukemia that has come back or does not respond to treatment and who are undergoing donor stem cell transplant.
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