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Subscription will auto renew annually.Over 10 million scientific documents at your fingertips You can also search for this author in Furthermore, AZL also resulted in reduced weight gain and fewer episodes of urinary pH <7.0.AZL appeared to diminish the incidence of HDMTx‐induced toxicities, including reducing oedema‐related weight gain. By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of Use Salicylates salicylates á9 antidepres- S alicylates acetazolamide acetazol amide .
Acetazolamide Chlorthalidone 2. With methane as reactant gas, abundant [MH] + ions were generally not produced. Shamash, J., Earl, H. & Souhami, R. Acetazolamide for alkalinisation of urine in patients receiving high-dose methotrexate.
In addition, since fluid overload is a common consequence of HDMTx treatment, the effect of AZL on fluid balance was also examined.This is a retrospective, single‐centred cohort study examining the mitigation of HDMTx‐induced toxicities by AZL in 92 patients over a 6‐year period.AZL showed a strong trend of preventing either AKI (as per CTCAE version 4.03) or delayed methotrexate elimination (>5 days), especially in males.
Ann Intern Med 102: 596Pitman SW, Frei E (1977) Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS.
Cancer 61: 2423Stark AN, Jackson G, Carey PJ, Arfeen S, Proctor SJ (1989) Severe renal toxicity due to intermediate-dose methotrexate. Despite its efficacy, nephrotoxicity is a potentially serious toxicity that could also exacerbate other methotrexate related toxicities and compromise dose intensity. Immediate online access to all issues from 2019.
Acetazolamide fiamilo— ride ics Acetazolamide 54 ßamphetam— ine lÇßChlorthali- done 2. In 6 cycles a single supplementary dose of sodium bicarbonate was necessary. A urinary pH of >7.5 was achieved in every cycle (13 cycles in 10 patients). Acetazolamide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. High‐dose methotrexate (HDMTx) is utilised in central nervous system (CNS) lymphoma and acute lymphoblastic leukemia (ALL) due to its ability to penetrate the blood–brain barrier.
In 1 study, acetazolamide was given to 10 patients during 13 cycles of high-dose methotrexate along with i.v. Lancet (336): 127Reggev A, Djerassi I (1988) Safety of administration of massive doses of methotrexate (50 g) with equimolar citrovorum factor rescue in adult patients. Methotrexate (MTX) is one of the most widely used anti‐cancer agents, and administration of high‐dose methotrexate (HDMTX) followed by leucovorin (LV) rescue is an important component in the treatment of a variety of childhood and adult cancers. 3065, Australia.Department of Haematology, St Vincent's Hospital, Melbourne, Victoria, AustraliaDepartment of Haematology, St Vincent's Hospital, Melbourne, Victoria, AustraliaDepartment of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, AustraliaUse the link below to share a full-text version of this article with your friends and colleagues. hydration.
Acetazolamide, 500 mg 6 hourly, has been used to alkalinise the urine in patients receiving high dose methotrexate.
Eur J Clin Oncol 24: 799Grem JL, King SA, Wittes RE, Leyland-Jones B (1988) The role of methotrexate in osteosarcoma. Cancer Treat Rep 61: 695Pyrhönen S, Valtonen M (1990) Response to doxorubicin/methotrexate/fluorouracil in advanced adenocarcinoma of pancreas or biliary tract (letter). Cancer Chemother Pharmacol 24: 243Department of Oncology, University College and Middlesex School of Medicine, 91 Riding House Street, W1P 8BTR, London, U.K.You can also search for this author in
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