PrEP medications are most effective when you take them every day. Generalized Weakness 11. Truvada (emtricitabine-tenofovir)." Itching 15. Available from: URL: https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf." In clinical trials, the following mean increases were reported in patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat for 96 weeks: fasted total cholesterol increased by 31 and 14 mg/dL, fasted LDL cholesterol by 18 and 7 mg/dL, fasted HDL cholesterol by 7 and 4 mg/dL, fasted triglycerides by 31 and 13 mg/dL.Increased fasting LDL cholesterol (greater than 190 mg/dL) has been reported in 8% and 4% of patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat. After that I began having terribly vivid nightmares and woke up several times throughout the night. Descovy (emtricitabine and tenofovir alafenamide) is a two-drug combination of two HIV nucleoside analog reverse transcriptase inhibitors (NRTIs), and is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 12 years of age and older. Gilead Sciences, Foster City, CA. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.

In a trial in renal dysfunction patients (baseline eGFR 30 to 69 mL/min) using emtricitabine plus tenofovir alafenamide with elvitegravir plus cobicistat, mean serum creatinine was 1.5 mg/dL at baseline and week 24; median UPCR was 161 mg/g at baseline and 93 mg/g at week 24.Proximal renal tubulopathy generally resolved or improved after tenofovir DF was stopped; however, decreased CrCl did not completely resolve in some HIV-1-infected patients after stopping the drug. "Antiretroviral prophylaxis for HIV prevention in heterosexual men and women." Gilead Sciences, Foster City, CA. During treatment with emtricitabine-tenofovir DF, 13% of patients lost at least 5% of BMD at the spine.Increased creatine kinase (at least 10 x ULN) has been reported in 9% and 7% of patients using emtricitabine plus tenofovir alafenamide and emtricitabine plus tenofovir DF, respectively, each with elvitegravir plus cobicistat.In virologically-suppressed tenofovir DF-treated patients who switched to emtricitabine plus tenofovir alafenamide with elvitegravir plus cobicistat, mean BMD increased between baseline and week 48; decreased BMD was also reported.Rhabdomyolysis, osteomalacia, muscular weakness, and myopathy may occur as a result of proximal renal tubulopathy.Rhabdomyolysis, muscular weakness, and myopathy have also been reported during postmarketing experience with tenofovir DF.-Common (1% to 10%): Decreased bone mineral density (BMD)-Common (1% to 10%): Increased creatine kinase, bone fractures, -Frequency not reported: Increased biochemical markers of bone metabolism, increased BMD, fractures (excluding fingers and toes)-Very common (10% or more): Increased creatine kinase-Very common (10% or more): Increased creatine kinase-Common (1% to 10%): Myalgia, arthralgia, back pain-Uncommon (0.1% to 1%): Rhabdomyolysis, muscular weakness-Frequency not reported: Decreased BMD, increased biochemical markers of bone metabolism-Postmarketing reports: Osteomalacia (manifested as bone pain and which may contribute to fractures)Hyperglycemia (greater than 250 mg/dL) has been reported in up to 2% of patients using emtricitabine-tenofovir DF.Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside analogs.Hypokalemia, lactic acidosis, and hypophosphatemia have also been reported during postmarketing experience with tenofovir DF.-Common (1% to 10%): Hyperglycemia, hypertriglyceridemia, increased or decreased serum glucose-Common (1% to 10%): Anorexia, increased serum glucose-Frequency not reported: Redistribution of body fat (lipodystrophy), increased glucose levels-Common (1% to 10%): Depression, insomnia, abnormal dreams, -Very common (10% or more): Insomnia, abnormal dreams-Common (1% to 10%): Rash event (including rash, maculopapular rash, exfoliative rash, generalized rash, macular rash, pruritic rash, vesicular rash)-Very common (10% or more): Rash event (including rash, pruritus, maculopapular rash, -Common (1% to 10%): Skin discoloration (palmar-plantar hyperpigmentation)-Postmarketing reports: Angioedema, urticaria, rash-Very common (10% or more): Rash event (including rash, pruritus, maculopapular rash, urticaria, vesiculobullous rash, pustular rash)Skin discoloration (hyperpigmentation) was very common in pediatric patients using emtricitabine.Rash has also been reported during postmarketing experience with tenofovir DF.Increased creatinine (1.1 to 1.3 x ULN: up to 2%; greater than 1.4 x ULN: less than 1%) has been reported with emtricitabine-tenofovir DF.In 2 trials in antiretroviral therapy-naive HIV-1-infected patients (median estimated glomerular filtration rate [eGFR] 115 mL/min at baseline) using emtricitabine plus tenofovir alafenamide with elvitegravir plus cobicistat, mean serum creatinine increased by 0.1 mg/dL from baseline to week 48; median UPCR was 44 mg/g at baseline and at week 48.

Baeten JM, Donnell D, Ndase P, et al.

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