Titration may proceed more rapidly, however, if clinically warranted, provided the patient is assessed frequently.The recommended dose for chronic stable or vasospastic angina is 5–10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. The effective antihypertensive oral dose in pediatric patients ages 6–17 years is 2.5 mg to 5 mg once daily. Doses in excess of 5 mg daily have not been studied in pediatric patients [see Clinical Pharmacology (12.4), Clinical Studies (14.1)].The usual initial antihypertensive oral dose of Amlodipine besylate tablets,USP is 5 mg once daily, and the maximum dose is 10 mg once daily.Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding Amlodipine besylate tablets,USP to other antihypertensive therapy.Adjust dosage according to blood pressure goals. In general, wait 7 to 14 days between titration steps. (See CLINICAL STUDIES for doses used in U.S. Clinical studies. Angina: The recommended dose for chronic stable or vasospastic angina is 5 to 10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency.
For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. Doses in excess of 5 mg daily have not been studied in pediatric patients [see Clinical Pharmacology (12.4), Clinical Studies (14.1)].The usual initial antihypertensive oral dose of amlodipine amlodipine besylate tablets are 5 mg once daily with a maximum dose of 10 mg once daily. Doses in excess of 5 mg daily have not been studied in pediatric patients [see Clinical Pharmacology (12.4), Clinical Studies (14.1)].The usual initial antihypertensive oral dose of amlodipine besylate tablets is 5 mg once daily with a maximum dose of 10 mg once daily.Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding amlodipine besylate tablets to other antihypertensive therapy.Adjust dosage according to each patient’s need. Most patients will require 10 mg for adequate effect. In general, titration should proceed over 7 to 14 days so that the physician can fully assess the patient’s response to each dose level. In patients with stable renal function, creatinine clearance can be reasonably well estimated using the equation of Cockcroft and Gault:The use of gabapentin tablets in patients less than 12 years of age with compromised renal function has not been studied.Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and dose should be adjusted based on creatinine clearance values in these patients.Administer gabapentin tablets orally with or without food.Inform patients that, should they divide the scored 600 mg or 800 mg gabapentin tablet in order to administer a half-tablet, they should take the unused half-tablet as the next dose. In clinical studies, the majority of patients required 10 mg [see Clinical Studies (14.4)].The effective antihypertensive oral dose in pediatric patients ages 6 to 17 years is 2.5 mg to 5 mg once daily.
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