But as this study suggests, aromatase inhibitors can cause more heart problems, as well as more bone loss (osteoporosis) and more broken bones, than tamoxifen, at least for the first few years of treatment. Women who took only an aromatase inhibitor and women who took only tamoxifen had similar risks of: Still, compared to women who took only tamoxifen or women who didn’t take hormonal therapy, the researchers found that women who took an aromatase inhibitor (either alone or after tamoxifen) had about a 27% higher risk of several less serious heart problems, including: "Our study is a comprehensive assessment of the impact aromatase inhibitors have on cardiovascular risk and provides reassurance that the hormone therapy to reduce breast cancer recurrence does not increase risk of the most fatal cardiovascular events," said Reina Haque, Ph.D., MPH, research scientist with Kaiser Permanente and one of the study’s authors. Tamoxifen, a selective estrogen receptor modulator (SERM), is one of the most well-known. Still, in some cases a premenopausal woman may take medicine to suppress the function of her ovaries and take an aromatase inhibitor. Cardiovascular events (CVEs) was considered as one of the primary cause to reduce the quality of life in breast cancer patients with aromatase inhibitors (AIs) treatment, which has not been sufficiently addressed. Hormonal therapy medicines work in two ways: There are several types of hormonal therapy medicines. If you’re a postmenopausal woman diagnosed with hormone-receptor-positive breast cancer, keep two things in mind when you and your doctor are deciding on a hormonal therapy treatment plan after surgery: Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer. Both tamoxifen and aromatase inhibitors can cause side effects. "Starting with tamoxifen and then switching to an aromatase inhibitor after several years -- rather than starting with an aromatase inhibitor and staying on it -- may reduce the risk of dying from causes other than An expert who worked on the landmark ATAC study that first showed the effectiveness of aromatase inhibitors disagrees.
The women were followed until December 2011, so the longest any woman was followed was 21 years and the shortest any woman was followed was 1 year. Heart Problems, Fracture Risk Greater With Extended Use of Aromatase Inhibitors to Treat Breast Cancer Extended use of aromatase inhibitors (AIs) in early breast cancer is associated with an increased risk of cardiovascular events and bone fractures, according to results from a study published in the Journal of the National Cancer Institute . Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones. Aromatase inhibitors aren’t commonly used to reduce recurrence risk in premenopausal women. Included studies were obtained from the databases of Embase, … The aim of this study was to assess the correlation between risk of CVEs and AIs in patients with breast cancer. The researchers grouped the women by the type of hormonal therapy they received: The researchers also controlled for any other health problems the women had, as well as any other medicines the women were taking, both of which could affect their risk of heart problems.
Tamoxifen can be used to treat both premenopausal and postmenopausal women. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones. Aromatase Inhibitors and Risk of Coronary Heart Disease and Stroke In the Arimidex, Tamoxifen, Alone or in Combination trial comparing tamoxifen with anastrozole, significantly fewer venous thromboembolic events and endometrial cancers were reported in the anastrozole group at 68 months of median fol- low-up. "This number needed to harm is relatively high," Amir says.For the study, Amir polled the results of seven trials of tamoxifen and aromatase inhibitors involving nearly 30,000 postmenopausal women with early In recent years, its use has been largely supplanted by aromatase inhibitors, which actually shut down the body's ability to make estrogen. Previous studies showed an association between heart failure and coronary heart disease and prior exposure to chest irradiation, 9 10 chemotherapy, 21 22 trastuzumab 23 24 and aromatase inhibitors. Breastcancer.org is a registered 501(c)(3) nonprofit organization dedicated to providing information and community to those touched by this disease. "A particular strength of our study is that we accounted for women's other potential cardiovascular risk factors as well as medication used to treat high blood pressure and high cholesterol." Research suggests that women who take hormone therapies called aromatase inhibitors may be at a slightly higher risk of heart problems. Aromatase inhibitors may cause muscle and joint aches and pains. The group of aromatase inhibitors includes the drugs: 1. anastrozole (Arimidex) 2. exemestane (Aromasin) 3. letrozole (Femara) Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke.
Other aromatase inhibitors are Aromasin and Femara. Aromatase inhibitors may cause muscle and joint aches and pains. Newer Breast Cancer Drugs May Carry Higher Risk of Heart Problems Than Tamoxifen: StudyDec.
Overall, the women had 3,711 cardiovascular events during the follow-up period.
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