This site needs JavaScript to work properly. Hydroxyurea (HU) is a simple organic compound currently used as a cancer chemotherapeutic agent. 1996 May;52(1):42-6. doi: 10.1002/(SICI)1096-8652(199605)52:1<42::AID-AJH7>3.0.CO;2-6.Randi ML, Ruzzon E, Luzzatto G, Tezza F, Girolami A, Fabris F.Silver RT, Woolf SH, Hehlmann R, Appelbaum FR, Anderson J, Bennett C, Goldman JM, Guilhot F, Kantarjian HM, Lichtin AE, Talpaz M, Tura S.Blood. Call your doctor at once if you have a fever, chills, body aches, extreme tiredness, shortness of breath, bruising, or unusual bleeding.You should not use hydroxyurea if you are allergic to it.Using hydroxyurea may increase your risk of developing other types cancer or leukemia. Hydroxyurea is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck). Hydroxyurea is also being studied in the treatment of other conditionsand types of cancer. Use the medicine exactly as directed.Hydroxyurea is usually taken once per day at the same time of day, with or without food. 2020 Feb;172:113742. doi: 10.1016/j.bcp.2019.113742.
Hydroxyurea is also approved to treat sickle cell anemia. Clipboard, Search History, and several other advanced features are temporarily unavailable. It acts specifically on the S-phase of the cell cycle by inhibiting the enzyme ribonucleoside diphosphate reductase, thereby hindering the reductive conversion of ribonucleotides to deoxyribonucleotides and thus limiting de novo DNA synthesis.
2020 Apr 9;18(4):200. doi: 10.3390/md18040200.Int J Mol Sci.
Skip Navigation. Taylor & Francis Wear protective clothing and use sunscreen when you are outdoors.Hydroxyurea can weaken your immune system.
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Nausea and throwing up (vomiting) 3. Epub 2019 Dec 11.World J Clin Cases.
Taylor & Francis Cancer cells need to make and repair DNA in order to grow and multiply 2.
Decrease appetite (decreased hunger)Note: Each of the side effects above was reported in 30% or greater of patients treated with hydroxyurea. 2020 Jan;10(1):39-45. doi: 10.15171/apb.2020.005. We comply with the HONcode standard for trustworthy health information - For best protection, wear disposable gloves when handling the pills.Do not open the hydroxyurea capsule or crush or chew a tablet. Select one or more newsletters to continue. Unable to load your collection due to an error
It acts specifically on the S-phase of the cell cycle by inhibiting the enzyme ribonucleoside diphosphate reductase, thereby hindering the reductive conversion of ribonucleotides to deoxyribonucleotides and thus limiting de novo DNA synthesis. Your cancer treatments may be delayed based on the results.This medicine can affect the results of certain medical tests. Available for Android and iOS devices.
Epub 2005 Nov 10.Ciavatta ML, Lefranc F, Vieira LM, Kiss R, Carbone M, van Otterlo WAL, Lopanik NB, Waeschenbach A.Mar Drugs.
Keep the bottle tightly closed when not in use.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
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Your blood will need to be tested often. Swallow the pill whole with a glass of water.Wash your hands before and after you handle hydroxyurea or the bottle that contains the pills. Diarrhea (loose bowel movements) 4.
2019 Dec 6;7(23):4091-4097. doi: 10.12998/wjcc.v7.i23.4091.Poddar S, Capparelli EV, Rosser EW, Gipson RM, Wei L, Le T, Jung ME, Radu C, Nikanjam M.Biochem Pharmacol.
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