Do not readminister to patients who have had angioedema with ARBs.• Electrolyte disturbances: Hyperkalemia may occur with angiotensin II receptor antagonists; risk factors include renal dysfunction, diabetes mellitus, and concomitant use of potassium-sparing diuretics, potassium supplements, and/or potassium-containing salts. If initial response is inadequate, may titrate dose after 1 to 2 weeks (maximum daily dose: Irbesartan 300 mg/hydrochlorothiazide 25 mg).Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).Ajmaline: Sulfonamides may enhance the adverse/toxic effect of Ajmaline.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Specifically, the risk of acute phosphate nephropathy may be enhanced. Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Angiotensin II Receptor Blockers may increase the serum concentration of Angiotensin-Converting Enzyme Inhibitors. Aminolevulinic Acid (Topical): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Topical). Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. Monitor blood pressure, renal function, and potassium if combined.Anticholinergic Agents: May increase the serum concentration of Thiazide and Thiazide-Like Diuretics.Antidiabetic Agents: Thiazide and Thiazide-Like Diuretics may diminish the therapeutic effect of Antidiabetic Agents. When unstented bilateral renal artery stenosis is present, use is generally avoided due to the elevated risk of deterioration in renal function unless possible benefits outweigh risks.• Renal impairment: Use irbesartan with caution with preexisting renal insufficiency. 3 DOSAGE FORMS AND STRENGTHS Irbesartan and hydrochlorothiazide 150/12.5 mg and 300/12.5 mg film-coated tablets are peach, biconvex, and oval with a heart debossed on one side and "2875" or "2876" on the reverse side... 4 CONTRAINDICATIONS Multivitamins/Minerals (with AE, No Iron): Thiazide and Thiazide-Like Diuretics may increase the serum concentration of Multivitamins/Minerals (with AE, No Iron). Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents. Alcohol (Ethyl): May enhance the orthostatic hypotensive effect of Thiazide and Thiazide-Like Diuretics.Alfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Aliskiren: May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers.
It may involve the head and neck (potentially compromising airway) or the intestine (presenting with abdominal pain). Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Beta2-Agonists: May enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics.Bile Acid Sequestrants: May decrease the absorption of Thiazide and Thiazide-Like Diuretics. Small increases in serum creatinine may occur following initiation; consider discontinuation only in patients with progressive and/or significant deterioration in renal function.• Skin cancer, nonmelanoma: Prolonged use (≥3 years) may increase the risk for squamous cell carcinoma up to 4 times and increase the risk for basal cell carcinoma up to 1.25 times compared to patients not treated with hydrochlorothiazide (Pedersen 2018; Pottegård 2017).• Sulfonamide (“sulfa”) allergy: The FDA-approved product labeling for many medications containing a sulfonamide chemical group includes a broad contraindication in patients with a prior allergic reaction to sulfonamides.
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