Teratogenic Effects. Trimethoprim side effects Get emergency medical help if you have signs of an allergic reaction : hives ; difficult breathing; swelling of your face, lips, tongue, or throat. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Pregnancy & Lactation If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects.

Adverse effects may occur more frequently in renally impaired patients but are not clearly related to increased serum concentrations of either drug. There are no absolute contraindications for Cystone. The fully electronic medical record was reviewed for alternative explanations for AKI, including the presence and stability of conditions such as volume depletion, heart failure or cirrhosis, that might diminish renal perfusion, as well as the concurrent administration of diuretics or other potentially nephrotoxic medications. Urinary tract infections (UTIs) are often mild and can sometimes resolve on their own with nothing more than ample fluids and maybe a mild over-the-counter (OTC) pain reliever. We specifically chose clindamycin because in the USA clinicians often choose between trimethoprim/sulfamethoxazole and clindamycin for the treatment of skin and soft tissue infections, and, further, clindamycin has not been identified as a cause of renal insufficiency.Because AKI occurred in our study in patients who had no specific new risk factors for renal impairment, trimethoprim/sulfamethoxazole should be considered an independent risk factor for AKI. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious DiseasesEffect of trimethoprim-sulfamethoxazole on the renal excretion of creatinine in manEffect of co-trimoxazole on normal creatinine clearanceEffect of co-trimoxazole on the glomerular filtration rate of healthy adultsEffect of co-trimoxazole and sulfamethoxazole on serum creatinine in normal subjectsEffects of moderate-dose versus high-dose trimethoprim on serum creatinine and creatinine clearance and adverse reactionsAcute interstitial nephritis due to drugs: review of the literature with a report of nine casesInterstitial nephritis caused by trimethoprim-sulfamethoxazole in renal transplant recipientsHyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazoleHyponatremia and/or hyperkalemia in patients treated with the standard dose of trimethoprim-sulfamethoxazoleTrimethoprim-sulfamethoxazole induced hyperkalemia in elderly patients receiving spironolactone: nested case-control studyAcute tubular necrosis following co-trimoxazole therapyDeterioration in renal function in association with co-trimoxazole therapyAdverse reactions to co-trimoxazole in hospitalized medical patientsAdverse reactions to trimethoprim-sulfamethoxazole in hospitalized patientsA large population-based follow-up study of trimethoprim-sulfamethoxazole, trimethoprim, and cephalexin for uncommon serious drug toxicityHyperkalaemia and non-oliguric renal failure associated with trimethoprimCo-trimoxazole-induced liver and renal failure.

In addition, a urinalysis was done during the trimethoprim/sulfamethoxazole treatment period in only 57.8% of AKI patients, so the incidence of acute interstitial nephritis, crystal-induced nephropathy and ATN could be underreported.We chose to include patients treated with clindamycin for skin and soft tissue infections as the comparator group because skin and soft tissue infections were the most common indication for trimethoprim/sulfamethoxazole in this study; a population treated for the same infection is most likely to have a similar incidence of comorbid conditions. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Other side effects not listed may also occur in some patients. Bactrim (sulfamethoxazole and trimethoprim) is a combination of antibiotics that treats infections such as urinary tract infections (UTIs), bronchitis, middle ear infections, for prevention of infections due to pneumococcus in organ transplant recipients, for the treatment or prevention of Pneumocystis carinii pneumonia, chancroid, and prevention of toxoplasma encephalitis in patients with AIDS. The addition of trimethoprim caused severe lithium toxicity in a 40-year-old woman with a schizoaffective disorder; following rehydration, she made a good recovery [ 681 ]. As well, some forms of this medi… All rights reserved. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

Patients in whom an unstable underlying disease state was present, a diuretic agent or a potentially nephrotoxic medication was recently added and/or the dosage was increased prior to the appearance of AKI were classified as having AKI possibly due to trimethoprim/sulfamethoxazole. Of these, 20 had <5 WBCs or RBCs (Table Data are shown as the number (%) of abnormal findings in 37 patients for whom a urinalysis was obtained.Data are shown as the number (%) of abnormal findings in 37 patients for whom a urinalysis was obtained.The mean ages of patients in the AKI and non-AKI groups were 63.8 ± 10.3 and 62.4 ± 12.8, respectively (Although the incidence of AKI appeared to be lower in patients aged 50–59 years than in patients ≥60 years, when we used a regression equation to analyse the tendency to develop AKI by decade of age there was no significant association of AKI with age (Two-hundred-and-eleven patients were treated with trimethoprim/sulfamethoxazole for skin or soft tissue infection, of whom 28 (13.3%) developed AKI.

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