Ondansetron (Zofran®) is a medicine used to treat nausea and vomiting that may be caused by surgery, chemotherapy, or radiation therapy. Animal studies have failed to reveal evidence of harm to the embryo, fetus, gestation period, perinatal/postnatal development, and/or fertility. CDC twenty four seven. Cardiac and other anomalies, including Ebstein's anomaly, have been reported in humans. SUMMARY: Ondansetron is a selective 5-HT 3 serotonin antagonist used in the treatment of chemotherapy-induced and post-operative nausea and vomiting, and off-licence for nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG). US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Zofran® is indicated for the prevention of nausea and vomiting associated with:Zofran is also indicated for the prevention of postoperative nausea and/or vomiting. Ondansetron is not approved for use by anyone younger than 4 years old. Healthcare professionals also prescribe ondansetron during pregnancy to reduce symptoms of nausea and vomiting, also known as “morning sickness.” Read the full scientific article A study from the Slone Epidemiology Center at Boston University, in collaboration with the Centers for Disease Control and Prevention (CDC), CDC’s National Center on Birth Defects and Developmental Disabilities (To learn more about our work in this area, visit the Parker SE, Van Bennekom C, Anderka M, & Mitchell AA. Newborns exposed throughout pregnancy may have signs/symptoms of lithium toxicity, but they were usually self-limiting and resolved within 1 to 2 weeks. See references Ondansetron Breastfeeding Warnings It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Obstetrics & Gynecology. Tell your doctor if you are pregnant. Evidence for the fetal safety of ondansetron, a 5-HT3 receptor antagonist that is commonly prescribed for nausea and vomiting during pregnancy, is limited and conflicting. There are no controlled data in human pregnancy.Breastfeeding is not recommended during use of this drug (AU, UK)Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. generic drugs) are not considered. Animal studies have reported evidence of interference with fertility, gestation, and fetal development. Dosage of drugs is not considered in the study. The study is based on ondansetron hydrochloride and lithium carbonate (the active ingredients of Zofran and Lithium carbonate, respectively), and Zofran and Lithium carbonate (the brand names). Available for Android and iOS devices. Ondansetron tablets are indicated for the prevention of nausea and vomiting associated with:Ondansetron tablets are also indicated for the prevention of postoperative nausea and/or vomiting. Pregnancy and Lactation with Ondansetron Available data do not reliably inform of association with adverse fetal outcomes when ondansetron is used during pregnancy; published epidemiological studies on the association between ondansetron and fetal outcomes have reported inconsistent findings and have important methodological limitations hindering … 2018; 132 (2): 385-394.Centers for Disease Control and Prevention.
Ondansetron for Treatment of Nausea and Vomiting during Pregnancy and the Risk of Birth Defects. Other drugs that have the same active ingredients (e.g. We comply with the HONcode standard for trustworthy health information - Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are breast-feeding a baby. Select one or more newsletters to continue. Saving Lives, Protecting People
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